White matter disruptions in patients with bipolar disorder
| Autor: | Roel A. Ophoff, Annabel Vreeker, Neeltje E.M. van Haren, Marco P. Boks, Lucija Abramovic, Annet H. van Bergen, Sanne Verkooijen, René S. Kahn |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Bipolar Disorder Lithium (medication) medicine.medical_treatment Image Processing Corpus callosum Gastroenterology Medical and Health Sciences 0302 clinical medicine Computer-Assisted Antimanic Agents Surveys and Questionnaires Image Processing Computer-Assisted Pharmacology (medical) Antipsychotic medication Psychiatry Brain Mapping Statistics Middle Aged Serious Mental Illness White Matter TBSS Psychiatry and Mental health medicine.anatomical_structure Diffusion Tensor Imaging Mental Health Neurology Biomedical Imaging Female Diffusion-weighted imaging medicine.drug Antipsychotic Agents Adult medicine.medical_specialty Lithium Article Statistics Nonparametric White matter 03 medical and health sciences Clinical Research Internal medicine Fractional anisotropy medicine Humans In patient Nonparametric Bipolar disorder Antipsychotic Biological Psychiatry Retrospective Studies Pharmacology Psychiatric Status Rating Scales business.industry Psychology and Cognitive Sciences medicine.disease 030227 psychiatry Brain Disorders Cross-Sectional Studies IQ Anisotropy Neurology (clinical) business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, vol 28, iss 6 |
| Popis: | Bipolar disorder (BD) patients show aberrant white matter microstructure compared to healthy controls but little is known about the relation with clinical characteristics. We therefore investigated the relation of white matter microstructure with the main pharmacological treatments as well its relation with IQ. Patients with BD (N = 257) and controls (N = 167) underwent diffusion tensor imaging (DTI) and comprehensive clinically assessments including IQ estimates. DTI images were analyzed using tract-based spatial statistics. Fractional anisotropy (FA) and Mean Diffusivity (MD) were determined. Patients had significantly lower FA and higher MD values throughout the white matter skeleton compared to controls. Within the BD patients, lithium use was associated with higher FA and lower MD. Antipsychotic medication use in the BD patients was not associated with FA but, in contrast to lithium, was associated with higher MD. IQ was significantly positively correlated with FA and negatively with MD in patients as well as in controls. In this large DTI study we found evidence for marked differences in FA and MD particularly in (but not restricted to) corpus callosum, between BD patients and controls. This effect was most pronounced in lithium-free patients, implicating that lithium affects white matter microstructure and attenuates differences associated with bipolar disorder. Effects of antipsychotic medication intake were absent in FA and only subtle in MD relative to those of lithium. The abnormal white matter microstructure was associated with IQ but not specifically for either group. |
| Databáze: | OpenAIRE |
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