Essential Oils and Hexane Extracts from Leaves and Fruits of Cistus monspeliensis. Cytotoxic Activity of ent-13-epi-Manoyl Oxide and its Isomers
| Autor: | Costas Dimas, Anargyros Loukis, Dimitrios Perdetzoglou, Costas Demetzos, Dimitra Angelopoulou |
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| Rok vydání: | 2001 |
| Předmět: |
Stereochemistry
Oxide Pharmaceutical Science Cistaceae Pharmacognosy Vinblastine Analytical Chemistry law.invention Structure-Activity Relationship chemistry.chemical_compound law Drug Discovery Oils Volatile Tumor Cells Cultured Cytotoxic T cell Cistus monspeliensis Essential oil Pharmacology Leukemia Plants Medicinal Chromatography Molecular Structure biology Plant Extracts Terpenes Organic Chemistry Biological activity biology.organism_classification Plant Leaves Hexane Complementary and alternative medicine chemistry Molecular Medicine |
| Zdroj: | Planta Medica. 67:168-171 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2001-11497 |
| Popis: | Essential oils and hexane extracts from Cistus monspeliensis L. leaves and fruits were analysed by GC-MS. Manoyl oxide and its isomers, 3 beta-hydroxy-manoyl oxide, 3 beta-hydroxy-13-epi-manoyl oxide, as well as 3 beta-acetoxy-13-epi-manoyl oxide were detected for the first time in C. monspeliensis L. Ent-13-epimanoyl oxide was isolated from the hexane extract of leaves and its structure was determined using spectroscopic methods. In vitro cytotoxic activity of ent-13-epi-manoyl oxide and mixtures of manoyl oxide isomers at 10(-4) M concentrations ranged from 11.1 to 32.2% of the activity for a vinblastine control evaluated against nine leukemic cell lines. The results showed that the manoyl oxide isomer mixtures as well as ent-13-epi-manoyl oxide exhibited a slight growth inhibiting activity. |
| Databáze: | OpenAIRE |
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