Synthesis andIn VitroAntibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles
| Autor: | Ali Asadipour, Negar Mohammadhosseini, Alireza Foroumadi, Bahram Letafat |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
biology
Chemistry General Chemistry Bacillus subtilis medicine.disease_cause biology.organism_classification Combinatorial chemistry In vitro Microbiology lcsh:Chemistry lcsh:QD1-999 Thiadiazoles Staphylococcus aureus Staphylococcus epidermidis medicine Nitro Antibacterial activity psychological phenomena and processes Bacteria |
| Zdroj: | E-Journal of Chemistry, Vol 8, Iss 3, Pp 1120-1123 (2011) |
| ISSN: | 2090-9810 0973-4945 |
| DOI: | 10.1155/2011/642071 |
| Popis: | In the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles (6a-c). Compounds6a-cwere testedin vitroby the conventional agar dilution method against a panel of microorganisms including gram-negative and gram-positive bacteria. Compound6bwith 5-(5-nitrofuran-2-yl)-residue on 1,3,4-thiadiazole scaffold have shown promising antibacterial activities against gram-positive bacteria includingStaphylococcus aureus, Staphylococcus epidermidisandBacillus subtilis. |
| Databáze: | OpenAIRE |
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