IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction
| Autor: | John W. Calvert, Madiha Zaidi, Ahsan Husain, Magnus Åbrink, David J. Lefer, Rebecca A. Torres, Nawazish Naqvi, Hussain Naib, Gunnar Pejler, Jonathan P. Lambert, Maria D. Berce, Robert M. Graham, Lin Tan, Thor Tejada, Murtaza Husain |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Programmed cell death Heart disease medicine.medical_treatment Myocardial Infarction Myocardial Reperfusion Injury 030204 cardiovascular system & hematology Biology Pharmacology 03 medical and health sciences Mice 0302 clinical medicine medicine Animals Myocardial infarction Insulin-Like Growth Factor I Receptor Cause of death Cardioprotection Multidisciplinary Protease Cell Death Hydrolysis Serine Endopeptidases Chymase Biological Sciences medicine.disease 030104 developmental biology Immunology |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 113(25) |
| ISSN: | 1091-6490 |
| Popis: | Significance Coronary heart disease is a leading cause of death worldwide. After acute myocardial infarction, early reperfusion limits infarct progression and improves clinical outcomes. However, despite reperfusion, the incidence of heart failure and cardiovascular deaths remains unacceptably high. Here, we report that a few days after ischemia, the reperfused heart transiently elaborates the cardioprotective polypeptide, insulin-like growth factor-1 (IGF-1). However, tissue IGF-1 levels increase only transiently because it is rapidly degraded by the chymase, mouse mast cell protease 4. Mouse mast cell protease 4 deletion promotes cardiac cell survival by reducing IGF-1 degradation, which ameliorates cardiac dysfunction caused by ischemic injury. Our findings suggest that chymase inhibition may be a viable therapeutic approach to enhance late cardioprotection in postischemic heart disease. |
| Databáze: | OpenAIRE |
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