Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study
| Autor: | Mattia Veronese, Anthony A. Grace, Philip McGuire, Gemma Modinos, Barbara Santangelo, James M. Stone, Oliver D. Howes, Robert A. McCutcheon, Mathilde Antoniades, Jesus Perez, Matilda Azis, Paul Allen, Matthijs G. Bossong, Ilaria Bonoldi |
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| Přispěvatelé: | McCutcheon, Robert A [0000-0003-1102-2566], Modinos, Gemma [0000-0002-7870-066X], Stone, James M [0000-0003-3051-0135], Veronese, Mattia [0000-0003-3562-0683], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Oncology Psychosis medicine.medical_specialty Magnetic Resonance Spectroscopy Dopamine Glutamic Acid Hippocampal formation Predictive markers Multimodal Imaging Article Young Adult 03 medical and health sciences Glutamatergic 0302 clinical medicine Neuroimaging Risk Factors Internal medicine Humans Medicine Longitudinal Studies Pharmacology business.industry Case-Control Studies Female Follow-Up Studies Magnetic Resonance Imaging Positron-Emission Tomography Psychotic Disorders Treatment Outcome Dopaminergic Glutamate receptor Case-control study medicine.disease 3. Good health 030227 psychiatry Psychiatry and Mental health Perception business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuropsychopharmacology Howes, O D, Bonoldi, I, McCutcheon, R A, Azis, M, Antoniades, M, Bossong, M, Modinos, G, Perez, J, Stone, J M, Santangelo, B, Veronese, M, Grace, A, Allen, P & McGuire, P K 2020, ' Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis : a multi-modal PET-magnetic resonance brain imaging study ', Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol. 45, no. 4, pp. 641-648 . https://doi.org/10.1038/s41386-019-0541-2 |
| ISSN: | 0893-133X |
| DOI: | 10.1038/s41386-019-0541-2 |
| Popis: | Preclinical models of psychosis propose that hippocampal glutamatergic neuron hyperactivity drives increased striatal dopaminergic activity, which underlies the development of psychotic symptoms. The aim of this study was to examine the relationship between hippocampal glutamate and subcortical dopaminergic function in people at clinical high risk for psychosis, and to assess the association with the development of psychotic symptoms. 1H-MRS was used to measure hippocampal glutamate concentrations, and 18F-DOPA PET was used to measure dopamine synthesis capacity in 70 subjects (51 people at clinical high risk for psychosis and 19 healthy controls). Clinical assessments were undertaken at baseline and follow-up (median 15 months). Striatal dopamine synthesis capacity predicted the worsening of psychotic symptoms at follow-up (r = 0.35; p p = 0.13). There were no differences in either glutamate (p = 0.5) or dopamine (p = 0.5) measures in the total patient group relative to controls. Striatal dopamine synthesis capacity at presentation predicts the subsequent worsening of sub-clinical total and psychotic symptoms, consistent with a role for dopamine in the development of psychotic symptoms, but is not strongly linked to hippocampal glutamate concentrations. |
| Databáze: | OpenAIRE |
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