Femur strength predictions by nonlinear homogenized voxel finite element models reflect the microarchitecture of the femoral neck
| Autor: | Andreas Reisinger, Gianluca Iori, Dieter H. Pahr, Caroline E. Wyers, Laura Peralta, Joop P. W. van den Bergh, Frans Heyer, Kay Raum |
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| Přispěvatelé: | Interne Geneeskunde, RS: NUTRIM - R3 - Respiratory & Age-related Health |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
CORTEX Materials science PROXIMAL FEMUR 0206 medical engineering Biomedical Engineering Biophysics CORTICAL BONE 02 engineering and technology Bone strength computer.software_genre VALIDATION 03 medical and health sciences 0302 clinical medicine Bone Density Voxel medicine Humans FAILURE Femur Femoral neck Mechanical Phenomena Bone mineral Hip fracture FRACTURE LOAD Finite element analysis TRABECULAR BONE HIP FRACTURE Hip fragility medicine.disease 020601 biomedical engineering Finite element method Biomechanical Phenomena Nonlinear system medicine.anatomical_structure Nonlinear Dynamics Osteoporosis Cortical bone Tomography X-Ray Computed computer 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Medical Engineering & Physics, 79, 60-66. ELSEVIER SCI LTD |
| ISSN: | 1350-4533 |
| Popis: | In the human femoral neck, the contribution of the cortical and trabecular architecture to mechanical strength is known to depend on the load direction.In this work, we investigate if QCT-derived homogenized voxel finite element (hvFE) simulations of varying hip loading conditions can be used to study the architecture of the femoral neck. The strength of 19 pairs of human femora was measured ex vivo using nonlinear hvFE models derived from high-resolution peripheral QCT scans (voxel size: 30.3 mu m). Standing and side-backwards falling loads were modeled. Quasi-static mechanical tests were performed on 20 bones for comparison. Associations of femur strength with volumetric bone mineral density (vBMD) or microstructural parameters of the femoral neck obtained from high-resolution QCT were compared between mechanical tests and simulations and between standing and falling loads.Proximal femur strength predictions by hvFE models were positively associated with the vBMD of the femoral neck (R-2 > 0.61, p 0.27, p 0.38, p |
| Databáze: | OpenAIRE |
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