Hypothyroidism induced by a transplanted fibrosarcoma in the rat
| Autor: | Jacqueline Claus-Walker |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Pituitary gland Neoplasm Transplantation endocrine system diseases Cyclophosphamide Endocrinology Diabetes and Metabolism Fibrosarcoma Thyroid Gland Thyrotropin Thyroid Function Tests Thyroid function tests chemistry.chemical_compound Endocrinology Hypothyroidism Internal medicine medicine Animals Busulfan medicine.diagnostic_test business.industry Tissue Extracts Thyroid Body Weight General Medicine Organ Size medicine.disease Rats medicine.anatomical_structure chemistry Pituitary Gland Methylcholanthrene Sarcoma Experimental business medicine.drug |
| Zdroj: | Acta endocrinologica. 55(3) |
| ISSN: | 0001-5598 |
| Popis: | Rats bearing a methylcholanthrene induced fibrosarcoma showed a decrease in thyroid weight, a decreased responsiveness to the goitrogenous effect of PTU and a significant decrease in 24 hour thyroidal 131I uptake. The thyroid of the tumourous rats was also shown to have a marked inability to synthesize thyroid hormones. The effects on the thyroid were found to accumulate proportionally to the time during which the tumour grew in the rat, and lead to a fibrous and degenerative invasion of the thyroid gland. In the rats bearing tumours, 1) the plasma and the pituitary TSH concentrations were within normal range; 2) large doses of exogenous TSH were able to stimulate the thyroid; 3) injection of saline extracts from the tumour elicited thyroid changes similar to those produced by the tumour. It is concluded from these data that the tumour produces an unusual hypothyroidism in the rat, which is caused by a substance elaborated by the tumour. The substance destroys progressively the thyroid tissue, leaving less and less thyroid parenchyma to respond to TSH and to secrete thyroid hormones. The substance seems to interfere with TSH at the thyroid level. |
| Databáze: | OpenAIRE |
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