Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population
| Autor: | Anne Kirstine Bang, Tina Kold Jensen, Niels Jørgensen, Jaime Mendiola, Shanna H. Swan, Lærke Priskorn, Anders Juul, N E Skakkebaek, Marianna Krause, Loa Nordkap |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Percentile Cross-sectional study Denmark Physiology Anal Canal 0302 clinical medicine Medicine media_common education.field_of_study 030219 obstetrics & reproductive medicine medicine.diagnostic_test Anthropometry Estradiol Sperm Count Rehabilitation Anogenital distance Obstetrics and Gynecology Scrotum Sperm Motility Original Article Luteinizing hormone Adult endocrine system AGDAS Urology media_common.quotation_subject Population MEDLINE AGDAP Fertility Semen analysis reproductive hormones Young Adult 03 medical and health sciences Semen quality semen quality Semen media_common.cataloged_instance Humans anogenital distance European union education business.industry urogenital system Reproductive hormones Odds ratio Luteinizing Hormone Semen Analysis Cross-Sectional Studies Reproductive Medicine Self Report Follicle Stimulating Hormone business Penis Demography |
| Zdroj: | Priskorn, L, Bang, A K, Nordkap, L, Krause, M, Mendiola, J, Jensen, T K, Juul, A, Skakkebaek, N E, Swan, S H & Jørgensen, N 2019, ' Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population ', Human reproduction (Oxford, England), vol. 34, no. 1, pp. 12-24 . https://doi.org/10.1093/humrep/dey326 |
| Popis: | STUDY QUESTION: Is anogenital distance (AGD) associated with semen quality and reproductive hormones in men from the general population? SUMMARY ANSWER: Short AGD measured from the anus to the base of scrotum (AGD(AS)) was associated with reduced sperm counts and morphology but not with sperm motility or reproductive hormones. WHAT IS KNOWN ALREADY: AGD is longer in males than in females. In rodents, AGD is a well-established and sensitive marker of disruption during the masculinization programming window in utero and it has been suggested to be so in humans as well. Therefore, the average AGD would be expected to be shorter in men with poor semen quality, which some studies have confirmed while others have not. STUDY DESIGN, SIZE, DURATION: This cross-sectional population-based study was of 1106 men included between 2012 and 2016. PARTICIPANTS/MATERIALS, SETTING, METHODS: Men from the general Danish population (median age 19 years), unselected with regard to fertility status and semen quality, delivered a semen sample, had a blood sample drawn, which was analyzed for concentrations of reproductive hormones, and answered a comprehensive questionnaire. They also had a physical examination performed including determination of AGD measured as the distance between anus and scrotum (AGD(AS)) and penis (AGD(AP)). Odds ratios (OR) and 95% CI were estimated for a man having abnormal semen parameters according to the World Health Organization’s reference values or a low/high concentration of reproductive hormones (defined as the lowest or highest 10%) depending on AGD. AGD was categorized in four strata: ≤10th percentile, 10th−30th percentile, 30th−50th percentile and >50th percentile. MAIN RESULTS AND THE ROLE OF CHANCE: Men with the 10% shortest AGD(AS) had a more than doubled risk (OR: 2.19, 95% CI: 1.40–3.42) of being in the subfertile range for either sperm concentration ( |
| Databáze: | OpenAIRE |
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