Immunoglobulin (Ig)M antibodies against oxidized cardiolipin but not native cardiolipin are novel biomarkers in haemodialysis patients, associated negatively with mortality
| Autor: | Peter Bárány, Anna G. Frostegård, Xiang Hua, Juan Jesus Carrero, Johan Frostegård, Jun Su, Olof Heimbürger, Peter Stenvinkel |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Risk Cardiolipins Immunology Apoptosis Cohort Studies chemistry.chemical_compound Renal Dialysis Interquartile range Cardiolipin Humans Immunology and Allergy Medicine Prospective Studies Aged Autoantibodies biology business.industry Hazard ratio Area under the curve Autoantibody Original Articles Middle Aged Antiphospholipid Syndrome Atherosclerosis Immunoglobulin M chemistry Cardiovascular Diseases beta 2-Glycoprotein I Antibodies Anticardiolipin Cohort biology.protein Biomarker (medicine) Female Antibody business Biomarkers |
| Zdroj: | Clinical and Experimental Immunology. 174:441-448 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/cei.12181 |
| Popis: | Summary The risk of premature death is high in haemodialysis (HD) patients. Antibodies against cardiolipin (anti-CL) are thrombogenic in diseases such as systemic lupus erythematosus (SLE). CL is easily oxidized (Ox) and plays a role in apoptosis. In this work we studied immunoglobulin (Ig)M anti-CL and anti-OxCL in HD-patients. We conducted an observational study with a prospective follow-up examining the relationship between anti-CL, anti-OxCL and mortality risk in a well-characterized cohort of 221 prevalent HD patients [56% men, median age 66 (interquartile range 51–74) years, vintage time 29 (15–58) months] with a mean follow-up period of 41 (20–48 months). According to the receiver operator characteristic (ROC) analysis, anti-OxCL [area under the curve (AUC) 0·62, P |
| Databáze: | OpenAIRE |
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