Overexpression of Family with Sequence Similarity 83, Member A (FAM83A) Predicts Poor Clinical Outcomes in Lung Adenocarcinoma
| Autor: | Bufan Xiao, Ye-Chun Lin, Jingtao Zhang, Bentong Yu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Male medicine.medical_specialty Low protein Multivariate analysis Lung Neoplasms Adenocarcinoma of Lung Kaplan-Meier Estimate 030204 cardiovascular system & hematology Disease-Free Survival Transcriptome 03 medical and health sciences 0302 clinical medicine Text mining Lab/In Vitro Research Internal medicine Databases Genetic medicine Humans RNA Messenger Retrospective Studies Regulation of gene expression Lung business.industry Computational Biology General Medicine Middle Aged medicine.disease Prognosis Oncogene Protein v-cbl Neoplasm Proteins Gene Expression Regulation Neoplastic medicine.anatomical_structure 030220 oncology & carcinogenesis Multivariate Analysis Immunohistochemistry Adenocarcinoma Female business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | BACKGROUND The aim of this study was to explore the expression levels of family with sequence similarity 83, member A (FAM83A) in lung adenocarcinoma (LUAD) and investigate its clinical prognostic value. MATERIAL AND METHODS Bioinformatics mining methods were used to predict the differential expression levels of FAM83A mRNA in LUAD and normal lung tissues based on the TCGA and Oncomine databases. Immunohistochemical staining was performed to demonstrate the FAM83A protein expression levels in 83 cases of LUAD combined with paired normal lung tissues. The correlation between clinicopathologic factors and FAM83A differential expression levels in LUAD was explored by the chi-square test. Kaplan-Meier univariate and Cox multivariate survival analyses were performed to investigate the clinical prognostic value of FAM83A expression in LUAD patients. RESULTS Results from TCGA and Oncomine databases revealed that FAM83A mRNA expression level was significantly higher in LUAD than that in normal lung tissues (both P |
| Databáze: | OpenAIRE |
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