Effects of harmaline on anxiety-related behavior in mice

Autor: Pascal Hilber, Pierre Chapillon
Přispěvatelé: Centre de Recherches sur les Fonctionnements et Dysfonctionnements Psychologiques (CRFDP), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Psychologie et Neurosciences de la Cognition et de l'affectivité (PSY-NCA), Normandie Université (NU)-Normandie Université (NU)
Rok vydání: 2005
Předmět:
Male
Elevated plus maze
Monoamine Oxidase Inhibitors
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
[SHS.PSY]Humanities and Social Sciences/Psychology
Experimental and Cognitive Psychology
Mice
Inbred Strains
Pharmacology
Anxiety
Harmaline
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
Mice
0302 clinical medicine
medicine
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Reaction Time
Animals
Elevated plus maze test
Maze Learning
030304 developmental biology
0303 health sciences
Analysis of Variance
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
Behavior
Animal
Dose-Response Relationship
Drug
[SCCO.NEUR]Cognitive science/Neuroscience
Motor control
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
3. Good health
Dose–response relationship
[SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis
Anxiogenic
chemistry
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
[SCCO.PSYC]Cognitive science/Psychology
Spatial learning
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Analysis of variance
medicine.symptom
Psychology
Neuroscience
030217 neurology & neurosurgery
Zdroj: Physiology & Behavior
Physiology & Behavior, 2005, 86 (1-2), pp.164-167. ⟨10.1016/j.physbeh.2005.07.006⟩
ISSN: 0031-9384
DOI: 10.1016/j.physbeh.2005.07.006⟩
Popis: International audience; Harmaline (HA) is a beta-carboline commonly known to provoke motor alterations through activation of cells in the inferior olive. In addition, this pharmacological agent also induces cognitive disturbances such as motor and spatial learning impairments. In order to complete and extend these data, we examined the effects of this drug on state anxiety in mice, employing elevated plus maze test. We report here that lower doses of harmaline (5-10 mg/kg) have anxiogenic since higher doses (20 mg/kg) have anxiolytic-like properties. Overall pattern of our behavioral results provides evidence that harmaline also acts on emotional reactivity in mice by influencing their decision making when placed in an anxiogenic situation. D
Databáze: OpenAIRE
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