Multimorbidity in asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA 2 LEN study

Autor: Karl A. Franklin, Viiu Blöndal, Anna James, Andrei Malinovschi, Bo Lundbäck, Fredrik Sundbom, Christer Janson, Roelinde Middelveld
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Allergy
Respiratory Medicine and Allergy
Anxiety
Immunoglobulin E
0302 clinical medicine
Cost of Illness
immune system diseases
Forced Expiratory Volume
Sleep Initiation and Maintenance Disorders
Immunology and Allergy
Lungmedicin och allergi
atopic dermatitis
biology
Depression
Atopic dermatitis
Middle Aged
Original Article
Female
IgE
Adult
medicine.medical_specialty
Immunology
Dermatitis
Atopic
03 medical and health sciences
rhinitis
Food allergy
Hypersensitivity
medicine
Humans
Skin Tests
Asthma
Inflammation
Sweden
food allergy
business.industry
Symptom burden
Multimorbidity
asthma
medicine.disease
Rhinitis
Allergic
Dermatology
respiratory tract diseases
030104 developmental biology
030228 respiratory system
Fractional Exhaled Nitric Oxide Testing
Asthma and Rhinitis
Concomitant
Quality of Life
biology.protein
ORIGINAL ARTICLES
business
Cell Adhesion Molecules
Biomarkers
Zdroj: Clinical and Experimental Allergy
ISSN: 1365-2222
0954-7894
DOI: 10.1111/cea.13759
Popis: Background: Asthma is common worldwide and a large part of subjects with asthma have concomitant allergic multimorbidity in the form of rhinitis and/or eczema. Objective: The aim of this study is to investigate whether the presence of allergic multimorbidity in asthma relates to allergic sensitization, allergic and respiratory symptoms, quality of life, inflammatory markers, lung function, use of medication and background factors. Methods: A total of 437 asthmatics from the (GA(2)LEN) cross-sectional survey in Sweden were grouped depending on the presence of rhinitis and/or eczema. The impact of allergic multimorbidity was assessed in terms of allergic sensitization, allergic and respiratory symptoms, quality of life, type-2 inflammatory markers (exhaled nitric oxide, eosinophil activation markers, periostin), lung function, use of medication and background factors. Results: Subjects with asthma, rhinitis and eczema were more likely to be sensitized to seasonal allergens (67% vs 32%, P < .001), food allergens (54% vs 18%, P < .001) and to have a higher degree of sensitization than subjects with only asthma (23% vs 10%, P < .001). Subjects with allergic multimorbidity more often had allergic reactions to food (28% vs 10%, P = .002), more respiratory symptoms and anxiety/depression (40% vs, 14%, P < .001) than subjects with only asthma, despite having similar levels of type 2 inflammatory markers. Individuals with allergic multimorbidity were more likely to be diagnosed with asthma before the age of 12 (48% vs 27%, P = .016) and to have maternal heredity for allergy (53% vs 33%, P = .011) than subjects with only asthma. Conclusion and clinical relevance: Asthmatics with allergic multimorbidity are more likely to be sensitized to seasonal aeroallergens, food allergens and they have a higher degree of sensitization compared with those with only asthma. Allergic multimorbidity is associated with respiratory and allergy symptoms, anxiety and/or depression.
Databáze: OpenAIRE
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