Identification of 5-Hydroxymethylfurfural (5-HMF) as an Active Component Citrus Jabara That Suppresses FcεRI-Mediated Mast Cell Activation
| Autor: | Michiko Kato, Yuka Hattori, Hiroko Kikuchi, Emi Watanabe, Ryota Uchida, Katsuumi Kobayashi, Keigo Nishida |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Citrus
Antioxidant Citrus jabara medicine.medical_treatment Stimulation mast cells Catalysis Article Cell Degranulation 5-HMF lcsh:Chemistry Inorganic Chemistry medicine cytokine Furaldehyde Food science Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology fermentation Spectroscopy Flavor degranulation Narirutin Chemistry Plant Extracts Receptors IgE Organic Chemistry Degranulation food and beverages General Medicine Immunoglobulin E allergy Computer Science Applications Cytokine lcsh:Biology (General) lcsh:QD1-999 Cytokines Fermentation Fermented Foods Inflammation Mediators |
| Zdroj: | International Journal of Molecular Sciences Volume 21 Issue 7 International Journal of Molecular Sciences, Vol 21, Iss 2472, p 2472 (2020) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21072472 |
| Popis: | Jabara (Citrus jabara Hort. ex Y. Tanaka) is a type of citrus fruit known for its beneficial effect against seasonal allergies. Jabara is rich in the antioxidant narirutin whose anti-allergy effect has been demonstrated. One of the disadvantages in consuming Jabara is its bitter flavor. Therefore, we fermented the fruit to reduce the bitterness and make Jabara easy to consume. Here, we examined whether fermentation alters the anti-allergic property of Jabara. Suppression of degranulation and cytokine production was observed in mast cells treated with fermented Jabara and the effect was dependent on the length of fermentation. We also showed that 5-hydroxymethylfurfural (5-HMF) increases as fermentation progresses and was identified as an active component of fermented Jabara, which inhibited mast cell degranulation. Mast cells treated with 5-HMF also exhibited reduced degranulation and cytokine production. In addition, we showed that the expression levels of phospho-PLC&gamma 1 and phospho-ERK1/2 were markedly reduced upon Fc&epsilon RI stimulation. These results indicate that 5-HMF is one of the active components of fermented Jabara that is involved in the inhibition of mast cell activation. |
| Databáze: | OpenAIRE |
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