A novel, abundant sodium channel expressed in neurons and glia
| Autor: | John H. Caldwell, DM Krzemien, PJ Yarowsky, Kristin L. Schaller, BK Krueger |
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| Rok vydání: | 1995 |
| Předmět: |
Nervous system
DNA Complementary Molecular Sequence Data In situ hybridization Biology Polymerase Chain Reaction Protein Structure Secondary Sodium Channels Complementary DNA Glial Fibrillary Acidic Protein medicine Animals Amino Acid Sequence RNA Messenger In Situ Hybridization Gene Library Neurons Messenger RNA Base Sequence Sequence Homology Amino Acid General Neuroscience Sodium channel Granule (cell biology) Brain Articles Blotting Northern Spinal cord Molecular biology Rats medicine.anatomical_structure nervous system Brainstem Oligonucleotide Probes Neuroglia |
| Zdroj: | The Journal of Neuroscience. 15:3231-3242 |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | A novel, voltage-gated sodium channel cDNA, designated NaCh6, has been isolated from the rat central and peripheral nervous systems. RNase protection assays showed that NaCh6 is highly expressed in the brain, and NaCh6 mRNA is as abundant or more abundant than the mRNAs for previously identified rat brain sodium channels. In situ hybridization demonstrated that a wide variety of neurons express NaCh6, including motor neurons in the brainstem and spinal cord, cerebellar granule cells, and pyramidal and granule cells of the hippocampus. RT-PCR and/or in situ hybridization showed that astrocytes and Schwann cells express NaCh6. Thus, this sodium channel is broadly distributed throughout the nervous system and is shown to be expressed in both neurons and glial cells. |
| Databáze: | OpenAIRE |
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