The Polymorphisms Of The Genotion Of Endothelial No-Synthase And The Diffusion Of Dyslipidemia At Arterial Hypertension In Saturation With Abdominal Explosion

Autor: Bondar, V. N., Yakimenko, E. A., Kolomiets, S. N., Chernyshova, E. S.
Rok vydání: 2018
ISSN: 1818-9385
DOI: 10.5281/zenodo.1319024
Popis: Bondar V. N., Yakimenko E. A., Kolomiets S. N., Chernyshova E. S. The polymorphisms of the genotion of endothelial NO-synthase and the diffusion of dyslipidemia at arterial hypertension in saturation with abdominal explosion. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2018;2(52):110-116. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.1319025 http://aptm.org.ua THE POLYMORPHISMS OF THE GENOTION OF ENDOTHELIAL NO-SYNTHASE AND THE DIFFUSION OF DYSLIPIDEMIA AT ARTERIAL HYPERTENSION IN SATURATION WITH ABDOMINAL EXPLOSION V. N. Bondar, E. A. Yakimenko, S. N. Kolomiets, E. S. Chernyshova Odessa National Medical University, Odessa, Ukraine vadim_bondar@ukr.net, K.Chernyshova.MD@gmail.com The сardiovascular risk in patients with arterial hypertension (AH) and abdominal obesity (AO) is largely determined by the severity and features of dyslipidemia, which is associated with endothelial dysfunction. The purpose of the research were analysis of the distribution of polymorphisms of eNOS gene and assessment of the features of dyslipidemia depending on the distribution of the isolated and combined polymorphisms of eNOS gene in patients with AH and AO in Ukrainian population. 128 patients with AH and AO were examined (ESC 2013, IDF 2005). In the surveyed group polymorphisms T (-786)C and G894T of eNOS gene were determined by PCR. Patients were divided into subgroups with isolated polymorphism T (-786)C (subgroup 1), with isolated polymorphism G894T (subgroup 2), with combination of two polymorphisms (subgroup 3) and with "normal genotypes" of eNOS gene (subgroup 4). In each subgroup we additionally studied the blood lipid fractions and type of dyslipidemia (Fredrickson’s classification). In the surveyed group, the frequency of isolated polymorphism T (-786)C was (17,9 %/23), isolated polymorphism G894T — (29,6 %/38), combination of polymorphisms T (-786)C and G894T — (35,9 %/46), "normal genotypes" of eNOS gene — (16,4 %/21). There is a high frequency of occurrence of isolated polymorphism G894T and combination of polymorphisms T (-786)C and G894T compared to isolated polymorphism T (-786)C and “normal genotypes” of eNOS gene. Type IIa dyslipidemia was predominant in subgroup (1) (58 %, r = 0,64, p = 0,04); in subgroup (2) — type III dyslipidemia (64 %, r = 0,72, p = 0,01); in the subgroup (3) — type IIb dyslipidemia (58 %, r = 0,66, p = 0,03); in the subgroup (4) — type III dyslipidemia (42 %, r = 0,56, p = 0,04). Thus, the features of dyslipidemia in patients with AH and AO is associated with polymorphism of eNOS gene. This association indicates the relationship of endothelial dysfunction with impaired lipid metabolism. The most unfavorable polymorphism, which is associated with dyslipidemia of very high atherogenic and cardiovascular risks, is a combination of polymorphisms T (-786)C and G894T of eNOS gene. Key words: arterial hypertension, abdominal obesity, endothelial dysfunction, dyslipidemia, gene polymorphism.  
Databáze: OpenAIRE