Inadequate response to intradermal hepatitis A vaccine
| Autor: | J. B. Kurtz, Richard J. Brindle, Christopher A. Morris, Rosemarie Berger |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Viral Hepatitis Vaccines Hepatitis A Vaccines General Veterinary General Immunology and Microbiology Intradermal route business.industry Hepatitis A vaccine Public Health Environmental and Occupational Health Pilot Projects Administration Cutaneous Hepatitis A Antibodies Hepatitis a virus Hepatitis A antibody Vaccination Route of administration Infectious Diseases Immunology Humans Molecular Medicine Medicine Hepatitis Antibodies Hepatovirus Viral disease business |
| Zdroj: | Vaccine. 12:483-484 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/0264-410x(94)90303-4 |
| Popis: | To assess the efficacy of the intradermal route of administration of hepatitis A vaccine we conducted a study in hospital laboratory workers. Forty-three volunteers were given three different combinations of intradermal and intramuscular hepatitis A vaccine and compared with 18 controls given intramuscular vaccine only. The geometric mean titres (GMT) after one, two and three intradermal doses of 0.1 ml each were 4.5, 28 and 143 IU l-1 respectively. The GMT after one intramuscular dose in the controls was 163 IU l-1. The results indicate that the response to intradermal hepatitis A vaccine is poor and its use cannot be recommended. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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