Diastereoselective Synthesis of (2R,4R)-2-Aryl-4-hydroxypyrrolidine: Preparation of the Side Chain of Novel Carbapenem
Autor: | Masaaki Hirose, Koji Yamada, Hajime Morishima, Shunji Sakuraba, Takashi Hashihayata, Hideaki Imamura, Yuichi Sugimoto, Hiroki Sakoh, Yasuhiro Goto |
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Rok vydání: | 2001 |
Předmět: | |
Zdroj: | Chemical and Pharmaceutical Bulletin. 49:1500-1502 |
ISSN: | 1347-5223 0009-2363 |
Popis: | Improved synthesis of the trans-3,5-disubstituted pyrrolidin-3-ylthio side-chain of the novel carbapenem 1 was achieved via stereoselective reduction of the 1-aryl-1-butanone derivative 5 and successive intramolecular cyclization of the resulting chiral alcohol 6. The 1-aryl-1-butanone derivative 5 was obtained by a coupling reaction of protected 4-hydroxy-2-pyrrolidone with aryl-Grignard reagent. |
Databáze: | OpenAIRE |
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