Studies of Monoclonal Antibodies Specific for Major Histocompatibility Complex Products of the Rat
Autor: | M. Fenner, Wigzell H, Hemmi S, Winterhalter K, Hans Binz |
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Rok vydání: | 2006 |
Předmět: |
Male
medicine.drug_class Immunology Immunoglobulins Major histocompatibility complex Monoclonal antibody Binding Competitive Subclass Antigen-Antibody Reactions Antigen Antibody Specificity Histocompatibility Antigens Rats Inbred BN medicine Animals biology Haplotype Class I Antigens Antibodies Monoclonal General Medicine Cytotoxicity Tests Immunologic Precipitin Tests Molecular biology Rats Rats Inbred ACI Rats Inbred Lew biology.protein Female Lymphocyte Culture Test Mixed Class II Antigens |
Zdroj: | Scandinavian Journal of Immunology. 21:549-563 |
ISSN: | 0300-9475 |
Popis: | Sixteen monoclonal antibodies against antigens coded for by the RT1 complex of the rat have been produced. Fourteen are specific for the a haplotype: six recognize class II and eight class I antigens. Two are specific for the 1 haplotype, one reacting with class I and the other with class II antigens. By means of these monoclonal antibodies four independent clusters of antigens for class I antigens of the a haplotype and three for class II antigens could be defined. The three antigenic sites of class II antigens reside on the same heterodimer. The monoclonals described here are characterized with regard to Ig class and subclass, pI, and complement-activating capacity. |
Databáze: | OpenAIRE |
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