The butyrophilin (BTN) gene family: from milk fat to the regulation of the immune response
| Autor: | Hassnae Afrache, Shanaiz Ainouche, Philippe Gouret, Pierre Pontarotti, Daniel Olive |
|---|---|
| Přispěvatelé: | Laboratoire d'Analyse, Topologie, Probabilités (LATP), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]
Immunology MESH: Gene Expression Regulation: physiology Biology MESH: Immune System: physiology 03 medical and health sciences MESH: Milk Human: metabolism 0302 clinical medicine Immune system Butyrophilin Phylogenetics MESH: Membrane Glycoproteins: genetics Genetics Gene family Animals Humans MESH: Animals 030304 developmental biology MESH: Lipid Metabolism 0303 health sciences Membrane Glycoproteins MESH: Humans Phylogenetic tree Butyrophilins Milk Human MESH: Milk Proteins: genetics Lipid Metabolism Milk Proteins Transmembrane protein Human genetics 3. Good health Milk Gene Expression Regulation MESH: Milk: metabolism Immune System Multigene Family biology.protein MESH: Multigene Family Antibody 030215 immunology |
| Zdroj: | Immunogenetics Immunogenetics, 2012, 64 (11), pp.781-94. ⟨10.1007/s00251-012-0619-z⟩ Immunogenetics, Springer Verlag, 2012, 64 (11), pp.781-94. ⟨10.1007/s00251-012-0619-z⟩ |
| ISSN: | 0093-7711 1432-1211 |
| DOI: | 10.1007/s00251-012-0619-z⟩ |
| Popis: | International audience; Butyrophilins (BTN) belong to the immunoglobulin (Ig) superfamily of transmembrane proteins. These molecules are of increasing interest to immunologists, as they share a structural homology with B7 family members at the extracellular domain level. Moreover, a role of these molecules has been suggested in the negative regulation of lymphocyte activation for almost all the BTN that have been studied. In addition, the expression of some BTN family members has been reported to be associated with autoimmune diseases. Over the last few years, the number of BTN and BTN-like members has greatly increased. In this study, the butyrophilin family in mammals has been revisited, using phylogenetic analysis to identify all the family members and the phylogenetic relations among them, and to establish a standard nomenclature. Fourteen BTN groups were identified that are not all conserved between mammalian species. In addition, an overview of expression profiles and functional BTN data demonstrates that these molecules represent a new area of investigation for the design of future strategies in the modulation of the immune system. |
| Databáze: | OpenAIRE |
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