Targeting TRIM5α in HIV Cure Strategies for the CRISPR-Cas9 Era
| Autor: | M T Boswell, Sarah Rowland-Jones, Weatherley Dav. |
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| Rok vydání: | 2017 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine PRYSPRY/B30.2 Genetic enhancement Immunology adeno-associated virus Biology ENCODE medicine.disease_cause Virus 03 medical and health sciences TRIM5α Genome editing medicine Immunology and Allergy CRISPR Adeno-associated virus Gene Innate immune system gene editing virus diseases Virology 030104 developmental biology Perspective HIV-2 HIV-1 CRISPR-Cas9 lcsh:RC581-607 |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 8 (2017) |
| ISSN: | 1664-3224 |
| Popis: | In the past decade, studies of innate immune activity against HIV-1 and other retroviruses have revealed a powerful array of host factors that can attack the virus at various stages of its life cycle in human and primate cells, raising the prospect that these antiviral factors could be manipulated in immunotherapeutic strategies for HIV infection. This has not proved straightforward: while HIV accessory genes encode proteins that subvert or destroy many of these restriction factors, others, such as human TRIM5α show limited potency against HIV-1. However, HIV-1 is much more susceptible to simian versions of TRIM5α: could this information be translated into the development of an effective gene therapy for HIV infection? Reigniting research into the restriction factor TRIM5α in the era of superior gene editing technology such as CRISPR-Cas9 presents an exciting opportunity to revisit this prospect. Copyright:. |
| Databáze: | OpenAIRE |
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