Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project

Autor: Florence Debacq-Chainiaux, Tilman Grune, Claudio Franceschi, Daniela Weber, Alexander Bürkle, Nicolle Breusing, Maria Moreno-Villanueva, Eugène H.J.M. Jansen, Ewa Sikora, Martijn E.T. Dollé, Olivier Toussaint, Antti Hervonen, Efstathios S. Gonos, Wolfgang Stuetz, Thilo Sindlinger
Přispěvatelé: Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, University of Tampere
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Gerontology
Aging
alpha-Tocopherol
Physiology
Ascorbic Acid
medicine.disease_cause
Biochemistry
Antioxidants
chemistry.chemical_compound
Lycopene
Malondialdehyde
Terveystiede - Health care science
education.field_of_study
lcsh:Cytology
alpha-Tocopherol/blood
Confounding
General Medicine
Middle Aged
Glutathione
3. Good health
Cohort
Female
Oxidation-Reduction
Research Article
Adult
Article Subject
Antioxidants/metabolism
Biolääketieteet - Biomedicine
Ascorbic Acid/blood
Population
Glutathione/blood
Oxidative Stress/physiology
Uric Acid/blood
03 medical and health sciences
ddc:570
medicine
Humans
Malondialdehyde/blood
Tyrosine/analogs & derivatives
lcsh:QH573-671
education
Lipid Peroxidation/physiology
Cell Biology
Ascorbic acid
Carotenoids
Uric Acid
Oxidative Stress
030104 developmental biology
chemistry
Carotenoids/blood
Tyrosine
Uric acid
Lipid Peroxidation
Biomarkers
Biomarkers/blood
Oxidative stress
Zdroj: Weber, D, Stuetz, W, Toussaint, O, Debacq-Chainiaux, F, Dollé, M, Jansen, E, Gonos, E S, Franceschi, C, Sikora, E, Hervonen, A, Breusing, N, Sindlinger, T, Moreno-Villanueva, M, Bürkle, A & Grune, T 2017, ' Associations between Specific Redox Biomarkers and Age in a Large European Cohort : The MARK-AGE Project ', Oxidative Medicine and Cellular Longevity, vol. 2017, 1401452, pp. 1401452 . https://doi.org/10.1155/2017/1401452
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
Oxidative Medicine and Cellular Longevity
ISSN: 1942-0994
1942-0900
DOI: 10.1155/2017/1401452
Popis: Oxidative stress and antioxidants play a role in age-related diseases and in the aging process. We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid,α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE. To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centers) and only participants aged ≥55 years were selected resulting in data from 1559 participants. These included subjects from (1) the general population, (2) members from long-living families, and (3) their spouses. In addition, 683 middle-aged reference participants (35–54 years) served as a control. After adjustment for age, BMI, smoking status, gender, and country, there were differences in protein carbonyls, malondialdehyde, 3-nitrotyrosine,α-tocopherol, cysteine, and glutathione between the 3 study groups. Protein carbonyls and 3-nitrotyrosine as well as cysteine, uric acid, and lycopene were identified as independent biomarkers with the highest correlation with age. Interestingly, from all antioxidants measured, only lycopene was lower in all aged groups and from the oxidative stress biomarkers, only 3-nitrotyrosine was increased in the descendants from long-living families compared to the middle-aged control group. We conclude that both lifestyle and genetics may be important contributors to redox biomarkers in an aging population.
Databáze: OpenAIRE
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