Bactericidal effects of antibiotics on slowly growing and nongrowing bacteria
| Autor: | C. E. Cherubin, Robert H.K. Eng, Elizabeth N. Tan, S. M. Smith, Frank T. Padberg |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Imipenem
Gram-negative bacteria Cefotaxime medicine.drug_class Gram-positive bacteria Antibiotics Microbial Sensitivity Tests Biology Gram-Positive Bacteria Microbiology Anti-Infective Agents Gram-Negative Bacteria medicine Pharmacology (medical) Pharmacology 4-Quinolones biochemical phenomena metabolism and nutrition Antimicrobial biology.organism_classification bacterial infections and mycoses Anti-Bacterial Agents Infectious Diseases Aminoglycosides Carbapenems Gentamicin Ofloxacin medicine.drug Research Article |
| Zdroj: | Antimicrobial agents and chemotherapy. 35(9) |
| ISSN: | 0066-4804 |
| Popis: | Antimicrobial agents are most often tested against bacteria in the log phase of multiplication to produce the maximum bactericidal effect. In an infection, bacteria may multiply less optimally. We examined the effects of several classes of antimicrobial agents to determine their actions on gram-positive and gram-negative bacteria during nongrowing and slowly growing phases. Only ciprofloxacin and ofloxacin exhibited bactericidal activity against nongrowing gram-negative bacteria, and no antibiotics were bactericidal (3-order-of-magnitude killing) against Staphylococcus aureus. For the very slowly growing gram-negative bacteria studied, gentamicin (an aminoglycoside), imipenem (a carbapenem), meropenem (a carbapenem), ciprofloxacin (a fluoroquinolone), and ofloxacin (a fluoroquinolone) exhibited up to 5.7 orders of magnitude more killing than piperacillin or cefotaxime. This is in contrast to optimally growing bacteria, in which a wide variety of antibiotic classes produced 99.9% killing. For the gram-positive and gram-negative bacteria we examined, antibiotic killing was greatly dependent on the growth rate. The clinical implications of slow killing by chemotherapeutic agents for established bacterial infections and infections involving foreign bodies are unknown. |
| Databáze: | OpenAIRE |
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