| Autor: |
Aslam Uddin, Javid Ahmad Malla, Harish Kumar, Manisha Kumari, Suman Sinha, Virender Kumar Sharma, Yashwant Kumar, Pinaki Talukdar, Mayurika Lahiri, Tushar Kanti Maiti, Partha Hazra |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Biochemistry. 61(21) |
| ISSN: |
1520-4995 |
| Popis: |
Establishing a potent scheme against α-synuclein aggregation involved in Parkinson's disease has been evaluated as a promising route to identify compounds that either inhibit or promote the aggregation process of α-synuclein. In the last two decades, this perspective has guided a dramatic increase in the efforts, focused on developing potent drugs either for retardation or promotion of the self-assembly process of α-synuclein. To address this issue, using a chemical kinetics platform, we developed a strategy that enabled a progressively detailed analysis of the molecular events leading to protein aggregation at the microscopic level in the presence of a recently synthesized 2-hydroxyisophthalamide class of small organic molecules based on their binding affinity. Furthermore, qualitatively, we have developed a strategy of disintegration of α-synuclein fibrils in the presence of these organic molecules. Finally, we have shown that these organic molecules effectively suppress the toxicity of α-synuclein oligomers in neuron cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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