Singlet Oxygen-Induced Furan Oxidation for Site-Specific and Chemoselective Peptide Ligation

Autor:	Annemieke Madder, Dimitris Kalaitzakis, Georgios Vassilikogiannakis, Kurt Hoogewijs, Eirini Antonatou, Andreas Baudot
Rok vydání:	2016
Předmět:	Light Hydrazone Peptide 010402 general chemistry Photochemistry Hydrazide 01 natural sciences Catalysis chemistry.chemical_compound Nucleophile Furan Furans Fluorescent Dyes chemistry.chemical_classification Singlet Oxygen 010405 organic chemistry Chemistry Singlet oxygen Organic Chemistry General Chemistry Combinatorial chemistry 0104 chemical sciences Covalent bond Click chemistry Peptides Oxidation-Reduction
Zdroj:	Chemistry (Weinheim an der Bergstrasse, Germany). 22(25)
ISSN:	1521-3765
Popis:	A novel chemoselective ligation methodology has been developed for the facile construction of peptide-based fluorescent probes. Furan-containing peptides were activated by singlet oxygen and covalently engaged by nitrogen nucleophiles to yield stable conjugates. Singlet oxygen was compatible with sensitive amino acid residues within the peptides and a range of fluorophores, bearing different functionalities, were successfully incorporated, illustrating the broad scope of the developed strategy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958f147d81fd205ae49b9394b884062a https://pubmed.ncbi.nlm.nih.gov/27113264 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.