Translocation yields in peripheral blood lymphocytes from control populations

Autor: Carita Lindholm, Ursula Oestreicher, David Lloyd, Joan Francesc Barquinero, Laurence Roy, G. Stephan, Leonardo Barrios, P. Voisin, M. R. Caballín, Tawn Ej, Firouz Darroudi, Fomina J, Alan Edwards, Jayne Moquet, Caroline A. Whitehouse
Přispěvatelé: National Radiological Protection Board (NRPB), Bundesamt für Strahlenschutz (BfS), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Radiation and Nuclear Safety Authority [Helsinki] (STUK), Universitat Autònoma de Barcelona (UAB), Leiden University Medical Centre [Leyde, Pays-Bas], Leiden University
Rok vydání: 2005
Předmět:
Male
[SDV]Life Sciences [q-bio]
Physiology
Chromosomal translocation
Translocation
Genetic
030218 nuclear medicine & medical imaging
0302 clinical medicine
Reference Values
Risk Factors
gender
Background Radiation
Lymphocytes
Child
Radiological and Ultrasound Technology
medicine.diagnostic_test
dosimetry
Smoking
article
Middle Aged
Europe
priority journal
030220 oncology & carcinogenesis
Meta-analysis
Female
Adult
lifestyle
Adolescent
Smoking habit
Translocation
Systematic variation
Biology
Risk Assessment
03 medical and health sciences
Age Distribution
Genetic
Radiation Monitoring
medicine
Dosimetry
Humans
Radiology
Nuclear Medicine and imaging
controlled study
human
Sex Distribution
fluorescence in situ hybridization
Aged
human cell
Confidence interval
Peripheral blood
United States
age
Immunology
Fluorescence in situ hybridization
meta analysis
peripheral lymphocyte
Zdroj: International Journal of Radiation Biology
International Journal of Radiation Biology, 2005, 81 (2), pp.139-145. ⟨10.1080/09553000500103082⟩
ISSN: 0955-3002
DOI: 10.1080/09553000500103082⟩
Popis: Purpose: To record the latest information on control levels of translocations in cultured human lymphocytes. Materials and methods: Control-level data from seven European laboratories that are using fluorescence in situ hybridization (FISH) techniques for retrospective biological dosimetry have been combined in a meta-analysis. After correction for the differing probe combinations used, tests of consistency are performed. The combined data have been used to test for individual variation, systematic variation with age, gender and smoking habits. Results: There is a strong variation of translocation yield with age but no variation was detectable with gender or smoking habits. After correction for age, homogeneity tests showed that about 10% of individuals were outside the 95% confidence limits as opposed to 5% expected. From a total of 385, there is an excess of about 20 individuals most of whom have an unexpectedly high yield of translocations. Conclusions: For retrospective biological dosimetry purposes a generic age-dependent control level can be assumed. No other lifestyle factors such as smoking appear to have a significant effect on translocation yield. © 2005 Taylor & Francis Group Ltd.
Databáze: OpenAIRE
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