Effect of Fetal Sex on Apoptosis-Regulating Proteins in Trophoblasts of Full-Term Human Placenta
| Autor: | Burçin Tuna, Mert Göl |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Placenta Apoptosis Chorionic Gonadotropin Human chorionic gonadotropin Andrology Sex Factors Pregnancy Internal medicine Fetal sex Humans Medicine reproductive and urinary physiology bcl-2-Associated X Protein Full Term Fetus urogenital system business.industry Infant Newborn Obstetrics and Gynecology Human placenta Fetal Blood medicine.disease Immunohistochemistry Trophoblasts Ki-67 Antigen Endocrinology Proto-Oncogene Proteins c-bcl-2 Reproductive Medicine embryonic structures Female Apoptosis Regulatory Proteins business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Gynecologic and Obstetric Investigation. 67:53-56 |
| ISSN: | 1423-002X 0378-7346 |
| DOI: | 10.1159/000161570 |
| Popis: | Objective: Pregnant women with female fetuses have higher maternal serum human chorionic gonadotropin (hCG) levels compared to those pregnant women with male fetuses. Apoptosis in the placenta has a role in hCG secretion. In the present study, we examined the effect of fetal gender on apoptosis-regulating proteins in the trophoblast cells of human term placenta. Study Design: 34 uncomplicated, singleton, term pregnancies, 17 had male and 17 had female fetuses, were recruited in the study. Apoptosis-regulating proteins of the trophoblast cells were measured by using immunohistochemistry for Bcl-2 and Bax. Staining index values were compared between the female and male pregnancies. Results: There were no sex differences in Bcl-2 and Bax proteins. There were no correlations between maternal serum and cord blood hCG levels, and staining index values of two proteins in trophoblast cells. Conclusions: The difference in maternal serum and cord blood hCG levels in correlation with fetal sex is not associated with apoptosis-regulating proteins in the trophoblast cells of human term placenta. |
| Databáze: | OpenAIRE |
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