Effects of a Novel Class III Antiarrhythmic Agent, NIP-142, on Canine Atrial Fibrillation and Flutter
| Autor: | Naoki Fujikura, Toru Yamashita, Hiroshi Inoue, Akira Fujiki, Hidehiko Nagasawa, Tomoyuki Matsuda |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Refractory period medicine.medical_treatment Antiarrhythmic agent Dogs Internal medicine Atrial Fibrillation medicine Carnivora Animals Benzopyrans Fibrillation biology business.industry Fissipedia Vagus Nerve Atrial fibrillation General Medicine medicine.disease biology.organism_classification Disease Models Animal Electrophysiology Atrial Flutter Anesthesia Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents Atrial flutter |
| Zdroj: | Circulation Journal. 66:185-191 |
| ISSN: | 1347-4820 1346-9843 |
| Popis: | The effects of a new benzopyran derivative, NIP-142, on atrial fibrillation (AF) and flutter (AFL) and on electrophysiological variables were studied in the dog. NIP-142 (3 mg/kg) was administered intravenously to pentobarbital-anesthetized beagles during vagally-induced AF and during AFL induced after placement of an intercaval crush. Isolated canine atrial tissues were studied using standard microelectrode technique. NIP-142 terminated AF in 5 of 6 dogs after an increase in fibrillation cycle length (CL) and prevented reinitiation of AF in all 6 dogs. NIP-142 terminated AFL in all 6 dogs without any appreciable change in flutter CL, and prevented reinitiation of AFL in all 6 dogs. NIP-142 prolonged atrial effective refractory periods (11±5%, 3±3%, 12±3%, and 10±5% from the baseline value at basic CLs of 150, 200, 300, and 350 ms, respectively) without changes in intraatrial conduction time. The prolongation of the atrial effective refractory period was greater in the presence of vagal stimulation. NIP-142 decreased action potential phase-1 notch and increased phase-2 plateau height without making any changes in the action potential duration, although it did reverse carbachol-induced shortening of the action potential duration. In conclusion, NIP-142 is effective in treating AFL and vagally-induced AF by prolonging atrial refractoriness. (Circ J 2002; 66: 185 - 191) |
| Databáze: | OpenAIRE |
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