Lipid profile and lipid oxidative modification parameters in the first trimester of high- risk pregnancies - possibilities for preeclampsia prediction
| Autor: | N. Karadžov Orlić, Željko Miković, Vesna Mandic-Markovic, S. Stanimirović, B. Damnjanović Pažin, Daniela Ardalic, Vesna Spasojevic-Kalimanovska, Milica Miljković, Aleksandra Stefanović, Petar Cabunac, Slavica Spasic, Gorica Banjac |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
030213 general clinical medicine medicine.medical_specialty Antioxidant Pregnancy High-Risk medicine.medical_treatment Clinical Biochemistry Oxidative phosphorylation 030204 cardiovascular system & hematology medicine.disease_cause Preeclampsia 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Internal medicine medicine TBARS Humans Triglycerides Placenta Growth Factor medicine.diagnostic_test business.industry Cholesterol HDL Atherogenic index of plasma Gestational age General Medicine medicine.disease Lipids High-risk pregnancies 3. Good health Oxidative Stress Pregnancy Trimester First Endocrinology ROC Curve Female Lipid profile business Oxidation-Reduction Biomarkers Oxidative stress |
| Zdroj: | Clinical Biochemistry |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/j.clinbiochem.2020.05.003 |
| Popis: | Objectives: The goal of this study was to investigate metabolic changes in lipids and oxidative stress parameters in the first trimester of pregnancy with the more specific aim of estimating the significance and strength of researched parameters in the prediction of preeclampsia. Design and Methods. The study included 87 high-risk pregnant (HRG) female subjects, 14 with developed preeclampsia (PEC) and 43 healthy pregnant female subjects matched for gestational age (CG). Thiobarbituric acid-reactive substances (TBARS) concentration, lipid hydroperoxides (LOOH), pro-oxidant antioxidant balance (PAB) and total oxidative status (TOS) were measured as oxidative stress markers, while total antioxidant capacity (TAC) was measured as an antioxidative defense parameter. The Atherogenic Index of Plasma (AIP) was calculated as the base 10 logarithm of the ratio of the plasma concentration of triglycerides (TG) to the plasma concentration of highdensity lipoprotein cholesterol (HDL-C), with each concentration expressed in mmol/L. Results: The results have shown that lipid indices, especially AIP, were significantly higher in the first trimester of HRG (p < 0.001) and PEC (p < 0.001). Oxidative stress parameters were significantlly higher, while TAC was significantly lower in HRG vs. CG [0.7 ± 0.15 vs 1.1 ± 0.16; (p < 0.001)] and in PEC [0.6 ± 0.12 vs 1.1 ± 0.16; (p < 0.001)] vs. CG. Also, in the HRG, results have shown an independent association of AIP with the preeclampsia development (p < 0.05), while placental growth factor did not show the expected level of significance (p = 0.648). Analysis of the Receiver Operating Characteristics (ROC) curves indicated that certain parameters included in the research model have very good diagnostic accuracy for preeclampsia (AUC = 0.856). Conclusions: AIP is associated with high-risk pregnancies. Furthermore, our results firmly underscored AIP as a potential marker for preeclampsia prediction. |
| Databáze: | OpenAIRE |
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