Impairment of blastogenic response of splenic lymphocytes from iron-deficient mice: in vivo repletion
| Autor: | Solo Kuvibidila, K M Nauss, Robert M. Suskind, B S Baliga |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Lipopolysaccharides
medicine.medical_specialty Anemia Iron T-Lymphocytes Lymphocyte Medicine (miscellaneous) Spleen Biology Lymphocyte Activation Mice Immune system Internal medicine Concanavalin A medicine Animals Ferrous Compounds Phytohemagglutinins Cells Cultured Anemia Hypochromic B-Lymphocytes Nutrition and Dietetics Body Weight Organ Size Iron deficiency T lymphocyte medicine.disease Mice Inbred C57BL Endocrinology medicine.anatomical_structure Iron-deficiency anemia biology.protein Female |
| Zdroj: | The American Journal of Clinical Nutrition. 37:15-25 |
| ISSN: | 0002-9165 |
| Popis: | Iron-deficiency anemia impaired the blastogenic response of splenic lymphocytes and partially purified T cells to Concanavalin A and phytohemagglutinin. The response of splenic lymphcoytes and partially purified B cells to bacterial lipopolysaccharide was also significantly impaired. Caloric restriction in pair-fed mice did not have any significant effect. Blastogenic response to the three mitogens was restored to normal after anemic mice were fed the regular diet containing 25 to 30 mg Fe/kg (FeSO4) for approximately 10 days. We also found that in the anemic mice, the mean wet weights per 100 g of body of spleen, heart, brain, and kidney increased, while those of the thymus and liver decreased. In the pair-fed mice only the mean wet weights of the liver significantly decreased. There was a small but significant decrease in the white blood count and peripheral lymphocyte count in the anemic but not the pair-fed mice. The mechanism by which iron deficiency impairs the cell-mediated immune response is discussed. Am J C/in Nutr 1983;37: 15-25. |
| Databáze: | OpenAIRE |
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