Sex-specific associations of basal steroid hormones and neuropeptides with Conduct Disorder and neuroendocrine mediation of environmental risk
| Autor: | Aranzazu Fernandez-Rivas, Nora Maria Raschle, Amy E Wells, Karen Gonzalez-Madruga, Christine M. Freitag, Réka Siklósi, Maider González de Artaza-Lavesa, Gregor Kohls, Amaia Hervás, Beate Herpertz-Dahlmann, Arne Popma, Anka Bernhard, Katharina Ackermann, Stephane A. De Brito, Graeme Fairchild, Christina Stadler, Anne Martinelli, Kerstin Konrad, Marietta Kirchner, Angeliki Konsta |
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| Přispěvatelé: | Pediatric surgery, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), University of Zurich, Bernhard, Anka |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Hydrocortisone Oxytocin Conduct disorder Basal (phylogenetics) 2738 Psychiatry and Mental Health 0302 clinical medicine Sex hormone-binding globulin 2736 Pharmacology (medical) Pharmacology (medical) Testosterone Gonadal Steroid Hormones FEMNAT-CD Progesterone biology Estradiol 10093 Institute of Psychology Psychiatry and Mental health 3004 Pharmacology 2728 Neurology (clinical) Neurology Female Steroids 2803 Biological Psychiatry hormones hormone substitutes and hormone antagonists medicine.drug 10190 Jacobs Center for Productive Youth Development Conduct Disorder medicine.medical_specialty Adolescent medicine.drug_class Clinical Neurology Neuropeptide 03 medical and health sciences SDG 3 - Good Health and Well-being Internal medicine Sex differences medicine Humans Environmental risk factors Biological Psychiatry Steroid hormones Pharmacology business.industry Neuropeptides Dehydroepiandrosterone Androgen Neurosecretory Systems 030227 psychiatry Endocrinology Estrogen 2808 Neurology biology.protein Neurology (clinical) alpha-Amylases business 150 Psychology 030217 neurology & neurosurgery Biomarkers Hormone |
| Zdroj: | European Neuropsychopharmacology, 49, 40-53. Elsevier Bernhard, A, Kirchner, M, Martinelli, A, Ackermann, K, Kohls, G, Gonzalez-Madruga, K, Wells, A, Fernández-Rivas, A, de Artaza-Lavesa, M G, Raschle, N M, Konsta, A, Siklósi, R K, Hervás, A, Herpertz-Dahlmann, B, de Brito, S A, Popma, A, Stadler, C, Konrad, K, Fairchild, G & Freitag, C M 2021, ' Sex-specific associations of basal steroid hormones and neuropeptides with Conduct Disorder and neuroendocrine mediation of environmental risk ', European Neuropsychopharmacology, vol. 49, pp. 40-53 . https://doi.org/10.1016/j.euroneuro.2021.03.016 Bernhard, A, Kirchner, M, Martinelli, A, Ackermann, K, Kohls, G, Gonzalez-Madruga, K, Wells, A, Fernández-Rivas, A, De Artaza-Lavesa, M G, Raschle, N M, Konsta, A, Siklósi, R, Hervás, A, Herpertz-Dahlmann, B, De Brito, S A, Popma, A, Stadler, C, Konrad, K, Fairchild, G & Freitag, C M 2021, ' Sex-specific associations of basal steroid hormones and neuropeptides with Conduct Disorder and neuroendocrine mediation of environmental risk ', European Neuropsychopharmacology, vol. 49, pp. 40-53 . https://doi.org/10.1016/j.euroneuro.2021.03.016 |
| ISSN: | 0924-977X |
| Popis: | Conduct Disorder (CD) is characterized by severe aggressive and antisocial behavior. The stress hormone system has frequently been investigated as a neurobiological correlate of CD, while other interacting neuroendocrine biomarkers of sex hormone or neuropeptide systems have rarely been studied, especially in females. We examined multiple basal neuroendocrine biomarkers in female and male adolescents with CD compared to healthy controls (HCs), and explored whether they mediate effects of environmental risk factors on CD. Within the FemNAT-CD study, salivary cortisol, alpha-amylase, testosterone, dehydroepiandrosterone-sulfate (DHEA-S), estradiol, progesterone, oxytocin, and arginine-vasopressin were measured under basal conditions in 166 pubertal adolescents with CD, and 194 sex-, age-, and puberty-matched HCs (60% females, 9–18 years). Further, environmental risk factors were assessed. Single hormone analyses showed higher DHEA-S, and lower estradiol and progesterone levels in both females and males with CD relative to HCs. When accounting for interactions between neuroendocrine systems, a male-specific sex hormone factor (testosterone/DHEA-S) predicted male CD, while estradiol and a stress-system factor (cortisol/alpha-amylase) interacting with oxytocin predicted female CD. Estradiol, progesterone, and oxytocin partly explained associations between early environmental risk and CD. Findings provide evidence for sex-specific associations between basal neuroendocrine measures and CD. Especially altered sex hormones (androgen increases in males, estrogen reductions in females) robustly related to CD, while basal stress-system measures did not. Early environmental risk factors for CD may act partly through their effects on the neuroendocrine system, especially in females. Limitations (e.g., basal neuroendocrine assessment, different sample sizes per sex, pubertal participants, exploratory mediation analyses) are discussed. |
| Databáze: | OpenAIRE |
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