An enhanced role for the recirculating lymphocyte in the neonatal immune system
| Autor: | Alan J Young, Lisbeth Dudler, Wendy L Marston |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Lymphocyte Immunology Immunological memory Biology Immunophenotyping Immune system Antigen Cell Movement Pregnancy medicine Animals Lymphocyte Count Lymph node Fetus Sheep Receptors Antigen T-Cell gamma-delta Immunohistochemistry Lymphocyte Subsets medicine.anatomical_structure Lymphatic system Animals Newborn Female Lymph Lymph Nodes Developmental Biology |
| Zdroj: | Developmental and comparative immunology. 24(6-7) |
| ISSN: | 0145-305X |
| Popis: | Lymphocytes continually recirculate between the blood and the tissues via the lymph independent of antigen. A great deal is known regarding both the physiology and the molecular mechanisms responsible for the process in adults. However, relatively little is known regarding the development of the recirculating lymphocyte pool in very young animals or fetuses. We have directly measured the recirculation of lymphocyte subsets in antigen-inexperienced newborn animals, and found extensive recirculation of T cells through both intestinal and subcutaneous lymph nodes. Apparent selective migration of recirculating lymphocytes could be attributed to subset-specific migration of gammadelta-T cells through subcutaneous lymph nodes. This clearly demonstrates that the preference for gammadelta-T cells to recirculate through SCLN is lineage specific, and independent of the presence of antigen. Most surprising was the observation that the recirculating lymphocyte pool was proportionately larger in neonatal animals than in adults, which correlated with the histological appearance of newborn lymph nodes. This data strongly suggests that development of the recirculating lymphocyte pool is inversely correlated with antigen exposure, and decreases in size with age and the acquisition of immunological memory. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect