Marginal decline in forced vital capacity is associated with a poor outcome in idiopathic pulmonary fibrosis
| Autor: | AU Wells, David M. Hansell, Derek Cramer, C J Zappala, T. V. Colby, Andrew G. Nicholson, Panagiota Latsi, EA Renzoni, R M du Bois |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Vital capacity Vital Capacity Severity of Illness Index FEV1/FVC ratio Idiopathic pulmonary fibrosis Predictive Value of Tests Risk Factors Diffusing capacity Internal medicine Outcome Assessment Health Care Pulmonary fibrosis Prevalence medicine Humans Proportional Hazards Models Carbon Monoxide business.industry Proportional hazards model Respiratory disease Hazard ratio Middle Aged respiratory system Prognosis medicine.disease Idiopathic Pulmonary Fibrosis respiratory tract diseases Surgery Cardiology Female business |
| Zdroj: | European Respiratory Journal. 35:830-836 |
| ISSN: | 1399-3003 0903-1936 |
| Popis: | In therapeutic studies in idiopathic pulmonary fibrosis (IPF), the low prevalence of significant change in pulmonary functional tests (PFTs) has been a major constraint. The prognostic value of "marginal" changes in PFTs in IPF and fibrotic non-specific interstitial pneumonia (NSIP) was evaluated. In patients with biopsy-proven IPF (n = 84) and NSIP (n = 72), forced vital capacity (FVC) and diffusing capacity of the lung for carbon monoxide (D( L,CO)) trends at 6 months were categorised as "significant" (FVC >10%; D(L,CO) >15%) or "marginal" (FVC 5-10%; D(L,CO) 7.5-15%). Proportional hazards analysis and time-dependent receiver operating characteristic methodology were used to examine PFT trends against mortality. In IPF, reductions in FVC were significant in 22 cases (26%) and marginal in 19 cases (23%). Mortality was higher in patients with a significant decline in FVC (hazard ratio (HR) 2.80, 95% CI 1.54-5.06; p |
| Databáze: | OpenAIRE |
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