Impact of donor-specific anti-HLA antibodies and donor KIR characteristics in haploidentical HSCT for beta-Thalassemia
| Autor: | Elvira Poggi, Javid Gaziev, Maria Troiano, Andrea Di Luzio, Pietro Sodani, Antonina Piazza, Marco Andreani, Manuela Testi, Giuseppe Testa, Michela Falco |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Graft failure Haploidentical HSCT KIR receptors anti-HLA antibodies T cell 03 medical and health sciences 0302 clinical medicine Haploidentical HSCT KIR receptors anti-HLA antibodies medicine Hla antibodies In patient biology business.industry lcsh:RC633-647.5 Beta thalassemia Hematology lcsh:Diseases of the blood and blood-forming organs medicine.disease Transplantation 030104 developmental biology Infectious Diseases medicine.anatomical_structure Immunology Cohort biology.protein Antibody business Scientific Letter 030215 immunology |
| Zdroj: | Mediterranean Journal of Hematology and Infectious Diseases 9 (2017). doi:10.4084/mjhid.2017.020 info:cnr-pdr/source/autori:Andreani M.; Testi M.; Sodani P.; Troiano M.; Luzio A.D.; Testa G.; Falco M.; Poggi E.; Gaziev J.; Piazza A./titolo:Impact of donor-specific anti-HLA antibodies and donor KIR characteristics in haploidentical HSCT for beta-Thalassemia/doi:10.4084%2Fmjhid.2017.020/rivista:Mediterranean Journal of Hematology and Infectious Diseases/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:9 Mediterranean Journal of Hematology and Infectious Diseases, Vol 9, Iss 1, Pp e2017020-e2017020 (2017) Mediterranean Journal of Hematology and Infectious Diseases |
| DOI: | 10.4084/mjhid.2017.020 |
| Popis: | In the present study we investigated the role of donor specific HLA antibodies (DSA) and donor KIR repertoire characteristics in a group of 18 patients affected by haemoglobinopathies who underwent haploidentical T cell depleted transplantation. Among these patients, 8 rejected the transplant while 10 had complete donor chimerism (CC). Five out of 8 patients (62.5%) who rejected graft had anti-HLA antibodies in the sera collected before transplant, while only 1 patient out of 10 (10%) with CC showed their presence (p=0,042). Notably, of the 5 HLA antibodies positive patients who rejected the graft 3 had DSA (2 for class I and 1 for class I and II) while none of the patients with CC had DSA. Among the 8 patients that experienced graft failure 4 were transplanted with a donor characterized by the lack of NK alloreactivity and 5 with a donor with a B content value |
| Databáze: | OpenAIRE |
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