Anti-metastatic effects of aqueous extract of Helixanthera parasitica
| Autor: | Chulabhorn Mahidol, Hunsa Prawat, Sanit Thongnest, Somsak Ruchirawat, Jisnuson Svasti, Rudee Surarit, Phaibul Punyarit, Kriengsak Lirdprapamongkol, Chantragan Srisomsap |
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| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
Matrigel Carcinoma Hepatocellular Plants Medicinal Antioxidant biology Plant Extracts medicine.medical_treatment Liver Neoplasms Biological activity Loranthaceae Thailand medicine.disease biology.organism_classification Antineoplastic Agents Phytogenic In vitro Metastasis Column chromatography Drug Discovery Immunology Cancer cell Tumor Cells Cultured medicine Humans |
| Zdroj: | Journal of Ethnopharmacology. 86:253-256 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/s0378-8741(03)00072-2 |
| Popis: | Metastasis, the spread of cancer in body, is a major cause of death. We have screened anti-metastatic activity of aqueous and dichloromethane extracts of several not previously studied Thai herbs, using an in vitro invasion test. This involves the in vitro invasion of HCC-S102, a hepatocellular carcinoma cell line derived from a Thai patient, through a reconstituted-basement membrane (Matrigel). The aqueous extract of a plant (Helixanthera parasitica) revealed a significant inhibitory effect on the cancer cell invasion, and showed antioxidant activity. The aqueous extract was partially purified by silica gel column chromatography, and the highest anti-metastatic activity fraction showed 83% inhibition of invasion with low cytotoxic effect. However, anti-metastatic activity was not associated with the antioxidant activity of the aqueous extract. |
| Databáze: | OpenAIRE |
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