Concurrent Treatment With Intratympanic Dexamethasone for Moderate-Severe Through Severe Bell's Palsy
Autor: | Sachiyo Katsumi, Toshiya Minakata, Akira Inagaki, Shingo Murakami |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male Steroid injection Systemic steroid Facial Paralysis Intratympanic dexamethasone macromolecular substances Antiviral Agents Dexamethasone Young Adult 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Bell's palsy Bell Palsy Odds Ratio Humans Combined Modality Therapy Medicine Prospective Studies 030223 otorhinolaryngology Prospective cohort study Glucocorticoids Injection Intratympanic business.industry Middle Aged medicine.disease Sensory Systems Clinical trial Otorhinolaryngology Valacyclovir Anesthesia Drug Therapy Combination Female Neurology (clinical) business 030217 neurology & neurosurgery |
Zdroj: | Otology & Neurotology. 40:e1018-e1023 |
ISSN: | 1537-4505 1531-7129 |
Popis: | To determine whether early intervention with intratympanic steroid injection, known as concurrent intratympanic steroid therapy, is effective as a supplement to systemic steroid therapy for treating moderate-severe to severe Bell's palsy.An open-label historical control trial.Tertiary referral center.A total of 35 Bell's palsy patients presenting with House-Brackmann grade IV or higher were treated with intratympanic steroid therapy concurrent with standard systemic treatment and compared with 108 patients treated with standard systemic therapy alone started within 7 days of onset.In the concurrent intratympanic steroid therapy group, patients received both 410 mg of prednisolone (standard dose) and 1.65 mg of intratympanic dexamethasone for 10 consecutive days. Patients in the control group received the standard dose, or more, of systemic prednisolone. Both groups were additionally treated with valacyclovir.The primary outcome measure was restoration of a House-Brackmann score of grade I.The rate of recovery to House-Brackmann Grade I was higher for the concurrent intratympanic steroid therapy group than for the control group (94% vs 73%, p = 0.008). The adjusted odds ratio was 5.47 (95% confidence interval: 1.18-25.21, p = 0.029).The recovery rate was higher for concurrent intratympanic steroid therapy treatment than for standard-of-care control treatment, regardless of whether steroid with lower or equivalent glucocorticoid action was administered. This result suggests that concurrent treatment with intratympanic steroid therapy is a potentially beneficial supplement to systemic steroid administration. |
Databáze: | OpenAIRE |
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