Cobalt(II)-Catalyzed Decarboxylative C–H Activation/Annulation Cascades: Regioselective Access to Isoquinolones and Isoindolinones

Autor:	Xinju Zhu, Xin-Qi Hao, Cong Du, Peng-Xiang Li, Jia-Heng Zhang, Mao-Ping Song, Jun-Long Niu
Rok vydání:	2016
Předmět:	Annulation 010405 organic chemistry Organic Chemistry chemistry.chemical_element Regioselectivity 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry Organic chemistry Physical and Theoretical Chemistry Selectivity Cobalt
Zdroj:	Organic Letters. 18:3610-3613
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.6b01632
Popis:	A new cobalt(II)-catalyzed decarboxylative C-H activation/annulation of benzamides and alkynyl carboxylic acids has been described. Alkynyl carboxylic acids were first employed as the coupling partners using inexpensive Co(OAc)2·4H2O as the catalyst. This method enables a switchable cyclization to isoquinolones and isoindolinones with excellent selectivity. Moreover, a catalytic amount of Ag2O was adopted as co-catalyst and O2 (from air) as a terminal oxidant for the preparation of isoquinolones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9580fcf49b5688886c282cc9e6e7a166 https://doi.org/10.1021/acs.orglett.6b01632 Zobrazit plný text záznamu