Combination of amphotericin B and flucytosine against neurotropic species of melanized fungi causing Primary cerebral phaeohyphomycosis
| Autor: | Haleh Rafati, Antonius J. M. M. Rijs, Roxana G. Vitale, A. H. G. Gerrits van den Ende, Wanqing Liao, Seyedmojtaba Seyedmousavi, Weiqing Pan, Shuwen Deng, G.S. de Hoog, A.H. Van Der Lee, Paul E. Verweij, Macit Ilkit |
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| Přispěvatelé: | Çukurova Üniversitesi, Biochemistry, Medical Microbiology & Infectious Diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Antifungal Antifungal Agents CIENCIAS MÉDICAS Y DE LA SALUD medicine.drug_class 030106 microbiology lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] Flucytosine Ciencias de la Salud NEUROTROPIC SPECIES Microbial Sensitivity Tests Microbiology 03 medical and health sciences purl.org/becyt/ford/3.3 [https] Rhinocladiella mackenziei Exophiala Amphotericin B medicine Humans Pharmacology (medical) COMBINATION Pharmacology Salud Ocupacional biology Drug Synergism biology.organism_classification medicine.disease Culture Media Drug Combinations Phaeohyphomycosis Infectious Diseases lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] Susceptibility MELANIZED FUNGI Saccharomycetales Cerebral Phaeohyphomycosis purl.org/becyt/ford/3 [https] Factor Analysis Statistical Antagonism medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy, 60, 2346-51 CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Antimicrobial Agents and Chemotherapy, 60, 4, pp. 2346-51 Antimicrobial Agents and Chemotherapy, 60(4), 2346-2351. American Society for Microbiology Antimicrobial Agents & Chemotherapy, 60(4), 2346-2351. American Society for Microbiology |
| ISSN: | 0066-4804 |
| Popis: | Primary central nervous system phaeohyphomycosis is a fatal fungal infection due mainly to the neurotropic melanized fungiCladophialophora bantiana,Rhinocladiella mackenziei, andExophiala dermatitidis.Despite the combination of surgery with antifungal treatment, the prognosis continues to be poor, with mortality rates ranging from 50 to 70%. Therefore, a search for a more-appropriate therapeutic approach is urgently needed. Ourin vitrostudies showed that with the combination of amphotericin B and flucytosine against these species, the median fractional inhibitory concentration (FIC) indices for strains ranged from 0.25 to 0.38, indicating synergy. By use of Bliss independence analysis, a significant degree of synergy was confirmed for all strains, with the sum ΔE ranging from 90.2 to 698.61%. No antagonism was observed. These results indicate that amphotericin B, in combination with flucytosine, may have a role in the treatment of primary cerebral infections caused by melanized fungi belonging to the orderChaetothyriales Furtherin vivostudies and clinical investigations to elucidate and confirm these observations are warranted. Fil: Deng, S.. First Hospital of Xinjiang Medical University; China. Second Military Medical University. Shanghai Institute of Medical Mycology; China Fil: Pan, W.. Second Military Medical University. Shanghai Institute of Medical Mycology; China Fil: Liao, W.. Second Military Medical University. Shanghai Institute of Medical Mycology; China Fil: de Hoog, G. S.. CBS-KNAW Fungal Biodiversity Centre; Países Bajos. University of Amsterdam; Países Bajos. King Abdulaziz University; Arabia Saudita Fil: Gerrits van den Ende, A. H. G.. CBS-KNAW Fungal Biodiversity Centre; Países Bajos. University of Amsterdam; Países Bajos Fil: Vitale, Roxana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina Fil: Rafati, H.. Erasmus University Medical Center; Países Bajos Fil: Ilkit, M.. University of Çukurova; Turquía Fil: Van der Lee, A. H.. Radboud University Medical Center; Países Bajos Fil: Rijs, A. J. M. M.. Radboud University Medical Center; Países Bajos Fil: Verweij, P. E.. Radboud University Medical Center; Países Bajos Fil: Seyedmousavi, S.. Radboud University Medical Center; Países Bajos. Erasmus University Medical Center; Países Bajos. Mazandaran University of Medical Sciences; Irán |
| Databáze: | OpenAIRE |
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