Triazolopyrimidines Target Aerobic Respiration in Mycobacterium tuberculosis

Autor:	Catherine Shelton, Matthew McNeil, Renee Allen, Lindsay Flint, Dara Russell, Bryan Berube, Aaron Korkegian, Yulia Ovechkina, Tanya Parish
Rok vydání:	2022
Předmět:	Electron Transport Complex IV Pharmacology Infectious Diseases Respiration Antitubercular Agents Cytochromes Humans Pharmacology (medical) Mycobacterium tuberculosis
Zdroj:	Antimicrobial Agents and Chemotherapy. 66
ISSN:	1098-6596 0066-4804
DOI:	10.1128/aac.02041-21
Popis:	We previously identified a series of triazolopyrimidines with antitubercular activity. We determined that Mycobacterium tuberculosis strains with mutations in QcrB, a subunit of the cytochrome bcc-aa3 supercomplex, were resistant.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9580d2ed6bb0502958c5cebcd33fe695 https://doi.org/10.1128/aac.02041-21 Zobrazit plný text záznamu