Biocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity
| Autor: | Sarah Wilson, Robert K. Delong, Sagar Rayamajhi, Santosh Aryal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
Materials science Biocompatibility media_common.quotation_subject Drug loading RNA stabilization medicine Biocompatible nanoparticles General Materials Science Doxorubicin Cytotoxicity Materials of engineering and construction. Mechanics of materials media_common Nano Express technology industry and agriculture RNA Condensed Matter Physics Bioavailability Drug delivery TA401-492 Biophysics Iron phosphate nanoparticles medicine.drug |
| Zdroj: | Nanoscale Research Letters Nanoscale Research Letters, Vol 16, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1556-276X 1931-7573 |
| Popis: | FePO4 NPs are of special interest in food fortification and biomedical imaging because of their biocompatibility, high bioavailability, magnetic property, and superior sensory performance that do not cause adverse organoleptic effects. These characteristics are desirable in drug delivery as well. Here, we explored the FePO4 nanoparticles as a delivery vehicle for the anticancer drug, doxorubicin, with an optimum drug loading of 26.81% ± 1.0%. This loading further enforces the formation of Fe3+ doxorubicin complex resulting in the formation of FePO4-DOX nanoparticles. FePO4-DOX nanoparticles showed a good size homogeneity and concentration-dependent biocompatibility, with over 70% biocompatibility up to 80 µg/mL concentration. Importantly, cytotoxicity analysis showed that Fe3+ complexation with DOX in FePO4-DOX NPs enhanced the cytotoxicity by around 10 times than free DOX and improved the selectivity toward cancer cells. Furthermore, FePO4 NPs temperature-stabilize RNA and support mRNA translation activity showing promises for RNA stabilizing agents. The results show the biocompatibility of iron-based inorganic nanoparticles, their drug and RNA loading, stabilization, and delivery activity with potential ramifications for food fortification and drug/RNA delivery. |
| Databáze: | OpenAIRE |
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