The Evolution (and Future) of Stereotactic Body Radiotherapy in the Treatment of Oligometastatic Disease
| Autor: | Benjamin E. Onderdonk, Stanley I. Gutiontov, Steven J. Chmura |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Stereotactic body radiation therapy Hematology Radiosurgery SABR volatility model Clinical trial 03 medical and health sciences Clinical Trials Phase II as Topic 0302 clinical medicine Clinical Trials Phase III as Topic Oncology Neoplasms 030220 oncology & carcinogenesis Humans Medicine Medical physics Neoplasm Metastasis business Stereotactic body radiotherapy Oligometastatic disease 030215 immunology |
| Zdroj: | Hematology/Oncology Clinics of North America. 34:307-320 |
| ISSN: | 0889-8588 |
| Popis: | This review outlines the history of the oligometastatic state from its first proposal to the current formulation. The article discusses the accumulating evidence for the biology of oligometastases, including clinical parameters, such as number and rate of progression, as well as ongoing molecular profiling efforts. The authors then discuss the current state of prospective clinical trials. They review the early site-specific as well as subsite agnostic studies using stereotactic body radiation therapy. Moreover, the article makes the case for why phase II trials should not be practice changing, and highlights the pivotal importance of accruing to phase III clinical trials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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