The Effects of Remifentanil on Hemodynamic Response Attenuation After Electroconvulsive Therapy Under Sevoflurane Anesthesia
| Autor: | Cemil Colak, Mukadder Sanli, Feray Erdil, Ülkü Özgül, Mahmut Durmuş, Gulay Erdogan Kayhan |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Methyl Ethers Mean arterial pressure medicine.medical_treatment Neuroscience (miscellaneous) Remifentanil Hemodynamics Loading dose Sevoflurane 03 medical and health sciences 0302 clinical medicine Piperidines Heart Rate Heart rate medicine Humans Anesthesia Arterial Pressure Electroconvulsive Therapy Saline Depressive Disorder Major business.industry 030227 psychiatry Oxygen Psychiatry and Mental health Anesthesia Recovery Period Anesthetics Inhalation Female business Anesthetics Intravenous 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Journal of ECT. 33:264-267 |
| ISSN: | 1533-4112 1095-0680 |
| DOI: | 10.1097/yct.0000000000000411 |
| Popis: | Purpose We evaluated the effects of a single loading dose of remifentanil (1 μg/kg) administered as an adjunct to sevoflurane, on the duration of seizure activity, recovery times, and hemodynamic profiles, during electroconvulsive therapy. Methods The patients were randomly allocated to receive sevoflurane-saline (Group SS) or sevoflurane-remifentanil (Group SR). Sevoflurane (8%) was initiated for anesthesia induction in both groups until loss of consciousness was achieved. Remifentanil was then administered to Group SR via a 1-μg/kg intravenous bolus. Patients in Group SS received saline in the same manner. Mean arterial pressure (MAP) and heart rate (HR) were recorded before anesthetic induction (T1), at the loss of consciousness (T2), and at 0, 1, 3, and 10 minutes after the electrical stimuli were completed (T3, T4, T5, and T6, respectively). Results Compared with the baseline values, HR increased significantly in Group SS at times T2 and T4 to T6 and decreased significantly in Group SR at time T2. When the groups were compared, we found that HR decreased significantly in Group SR at T2 and T4 to T6. Compared with baseline, MAP increased in Group SS between T3 and T6, and MAP decreased in Group SR at T2 and increased at T3 to T4. Mean arterial pressure decreased to a greater extent in Group SR than in Group SS during the T2 to T6 period. There were no group differences in seizure duration or recovery time. Conclusions The addition of 1-μg/kg remifentanil to anesthetic induction with sevoflurane attenuated the acute hemodynamic response to electroconvulsive therapy under sevoflurane anesthesia without adversely affecting the duration of seizure activity or the recovery profile. |
| Databáze: | OpenAIRE |
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