Polycystic ovary syndrome offspring display increased oxidative stress markers comparable to gestational diabetes offspring
| Autor: | Christos Adamopoulos, Evanthia Diamanti-Kandarakis, Dimitrios Hassiakos, Nicolaos Vitoratos, Christos Iavazzo, Georgios Boutzios, Sarantis Livadas, Christina Piperi |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Glycation End Products Advanced medicine.medical_specialty endocrine system diseases Offspring medicine.medical_treatment Insulin resistance Pregnancy Internal medicine medicine Humans Prospective Studies Glycated Hemoglobin Anthropometry business.industry Waist-Hip Ratio Polycystic ovary syndrome (PCOS) Insulin Infant Newborn nutritional and metabolic diseases Obstetrics and Gynecology medicine.disease Polycystic ovary female genital diseases and pregnancy complications Gestational diabetes Diabetes Gestational Oxidative Stress Endocrinology Reproductive Medicine Multivariate Analysis Population study Female business Head Biomarkers Polycystic Ovary Syndrome |
| Zdroj: | Fertility and sterility. 99(3) |
| ISSN: | 1556-5653 |
| Popis: | Objective To study oxidative stress (OS) markers on neonates. The specific aim was to evaluate advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) serum levels along with the hormonal/metabolic profile and their possible relationship in a cohort of polycystic ovary syndrome PCOS(N) and gestational diabetes GDM(N) neonates and their mothers PCOS(M) and GDM(M). Design Prospective controlled study. Setting Academic medical center. Patient(s) The study population comprised 151 mother/neonate pairs. Intervention(s) Diet and/or insulin administration in GDM(M). Main Outcome Measure(s) Anthropometric, metabolic, hormonal parameters, and OS markers. Result(s) The AGEs and AOPPs were higher in PCOS(M) and GDM(M) compared with controls (M). The same significant difference was observed in the corresponding groups of neonates. A strong relationship between mothers and neonates regarding AGEs ( r = 0.605) and AOPPs levels ( r = 0.735) was disclosed. Analogous findings were observed regarding androgens and insulin resistance in mothers and neonates, respectively. Conclusion(s) The present study demonstrated that in PCOS(N), the OS status was similar to that of GDM(N) and strongly associated with their mothers' oxidative status. These findings may have clinical implications, as exposure of PCOS(N) to high OS levels during pregnancy could affect several health issues of neonates. |
| Databáze: | OpenAIRE |
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