Lack of prognostic value of epidermal growth factor receptor in a series of 229 T1/T2, N0/N1 breast cancers, with well defined prognostic parameters

Autor: Pasquier D, M.H. Panh, J. Marron-Charrière, Béatrice Rostaing-Puissant, Marc Colonna, Edmond M. Chambaz, Michel Bolla, M. Chedin, P. Winckel
Rok vydání: 1994
Předmět:
Zdroj: Breast Cancer Research and Treatment. 29:265-270
ISSN: 1573-7217
0167-6806
DOI: 10.1007/bf00666480
Popis: The prognostic value of epidermal growth factor receptor (EGF-R) was prospectively assessed in a series of 229 clinical T1-T2, N0-N1 breast carcinomas diagnosed between May 1987 and October 1989. EGF-R expression was determined by measuring the specific Bmax of 125I EGF to tumor plasma membrane preparations. Tumor with a Bmaxor = 3 fmol/mg of protein were considered positive with regard to EGF-R expression. With a median follow-up of 34 months, the 3-year overall and disease-free survivals are respectively 92% and 88% for EGF-Ror = 3, and 91% and 86% EGF-R3 fmol, showing no significant difference, even when comparing axillary lymph node status. We did not succeed in finding an EGF-R cut-off value which might be significant in univariate analysis. Multivariate analysis of our data indicates that pT (p = 0.001), pN (p = 0.04), and Scarff-Bloom grade (p = 0.04) are the only significant predictors of disease-free survival among the parameters investigated in this study.
Databáze: OpenAIRE
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