Development of Atopic Dermatitis in Mice Transgenic for Human Apolipoprotein C1
| Autor: | Tonny Lagerweij, C. Persoon-Deen, Jimmy F.P. Berbée, Louis M. Havekes, Arnold P. Oranje, Errol P. Prens, Lex Nagelkerken, Perry Verzaal |
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| Přispěvatelé: | TNO Kwaliteit van Leven, Dermatology, University of Groningen |
| Rok vydání: | 2008 |
| Předmět: |
Male
Neutrophils Administration Topical Immunoglobulin E Biochemistry immunoglobulin E chemistry.chemical_compound Mice Adrenal Cortex Hormones inflammatory cell lipid metabolism Mast Cells biology integumentary system atopic dermatitis article Atopic dermatitis medicine.anatomical_structure priority journal Liver histopathology Female corticosteroid PROTEIN ANTIGEN lichenoid eruption ECZEMA Mice Transgenic Physiological Sciences Dermatology Article animal tissue Dermatitis Atopic Dermis SDG 3 - Good Health and Well-being medicine Animals Humans controlled study Biology protein expression Molecular Biology mouse Transepidermal water loss Apolipoprotein C-I nonhuman Cholesterol Pruritus Lipid metabolism apolipoprotein C1 Cell Biology medicine.disease Eosinophils chemistry Immunology biology.protein Apolipoprotein C1 Epidermis SKIN Spongiosis |
| Zdroj: | Journal of Investigative Dermatology, 5, 128, 1165-1172 Journal of Investigative Dermatology, 128(5), 1165-1172. Nature Publishing Group Journal of Investigative Dermatology, 128(5), 1165-1172. ELSEVIER SCIENCE INC |
| ISSN: | 0022-202X 1165-1172 |
| DOI: | 10.1038/sj.jid.5701182 |
| Popis: | Mice with transgenic expression of human apolipoprotein C1 (APOC1) in liver and skin have strongly increased serum levels of cholesterol, triglycerides, and free fatty acids, indicative of a disturbed lipid metabolism. Importantly, these mice display a disturbed skin barrier function, evident from increased transepidermal water loss, and spontaneously develop symptoms of dermatitis including scaling, lichenification, excoriations, and pruritus. Histological analysis shows increased epidermal thickening and spongiosis in conjunction with elevated numbers of inflammatory cells (eosinophils, neutrophils, mast cells, macrophages, and CD4+ T cells) in the dermis. In addition, affected mice have increased serum levels of IgE and show abundant IgE+ mast cells in the dermis. Partial inhibition of disease could be achieved by restoration of the skin barrier function with topical application of a lipophilic ointment. Furthermore, the development of atopic dermatitis in these mice was suppressed by corticosteroid treatment. These findings in APOC1(+/+) mice underscore the role of skin barrier integrity in the pathogenesis of atopic dermatitis. © 2007 The Society for Investigative Dermatology. |
| Databáze: | OpenAIRE |
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