Genetic Contribution of MHC Class II Genes in Susceptibility to West Nile Virus Infection
| Autor: | Zissis Mamuris, Constantina Politis, Anna Papa, Charalambos Billinis, Constantina A. Sarri, Agoritsa Baka, Christos Hadjichristodoulou, Athanasios Tsakris, Maria Markantoni, Costas Stamatis, Danai Pervanidou, Malwest |
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| Rok vydání: | 2016 |
| Předmět: |
RNA viruses
Male 0301 basic medicine Heredity lcsh:Medicine MHC Class II Gene Major Histocompatibility Complex Geographical Locations Gene Frequency Ethnicities lcsh:Science Pathology and laboratory medicine HLA-D Antigens Heterozygosity Multidisciplinary Greece biology Homozygote Exons Medical microbiology Middle Aged 3. Good health Europe Flavivirus Infectious Diseases Viruses Female Pathogens West Nile virus Encephalitis Research Article Infectious Disease Control Immunology 030106 microbiology Major histocompatibility complex Microbiology 03 medical and health sciences Genetics medicine Humans Genetic Predisposition to Disease Allele Allele frequency Alleles Medicine and health sciences Polymorphism Genetic Biology and life sciences Flaviviruses Viral encephalitis lcsh:R Organisms Viral pathogens Case-control study Greek People medicine.disease biology.organism_classification Virology Microbial pathogens 030104 developmental biology Genetic Loci Case-Control Studies People and Places biology.protein lcsh:Q Clinical Immunology Population Groupings Clinical Medicine West Nile Fever |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 11, p e0165952 (2016) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0165952 |
| Popis: | WNV is a zoonotic neurotropic flavivirus that has recently emerged globally as a significant cause of viral encephalitis. The last five years, 624 incidents of WNV infection have been reported in Greece. The risk for severe WNV disease increases among immunosuppressed individuals implying thus the contribution of the MHC locus to the control of WNV infection. In order to investigate a possible association of MHC class II genes, especially HLA-DPA1, HLA-DQA1, HLA-DRB1, we examined 105 WNV patients, including 68 cases with neuroinvasive disease and 37 cases with mild clinical phenotype, collected during the period from 2010 to2013, and 100 control individuals selected form the Greek population. Typing was performed for exon 2 for all three genes. DQA1*01:01 was considered to be "protective" against WNV infection (25.4% vs 40.1%, P = 0.004) while DQA1*01:02 was associated with increased susceptibility (48.0% vs 32.1%, P = 0.003). Protection against neuroinvasion was associated with the presence of DRB1*11:02 (4.99% vs 0.0%, P = 0.018). DRB1*16:02 was also absent from the control cohort (P = 0.016). Three additional population control groups were used in order to validate our results. No statistically significant association with the disease was found for HLA-DPA alleles. The results of the present study provide some evidence that MHC class II is involved in the response to WNV infection, outlining infection "susceptibility" and "CNS-high-risk" candidates. Furthermore, three new alleles were identified while the frequency of all alleles in the study was compared with worldwide data. The characterization of the MHC locus could help to estimate the risk for severe WNV cases in a country. |
| Databáze: | OpenAIRE |
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