Platelet PlA2 polymorphism and platelet activation are associated with increased troponin I release after cardiopulmonary bypass
Autor: | Stephen Pfau, Parag Patel, Christine S. Rinder, Manuel L. Fontes, Jill Crouch, Brian R. Smith, Joseph P. Mathew, J. Greg Howe, Henry M. Rinder |
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Rok vydání: | 2002 |
Předmět: |
Adult
Male medicine.medical_specialty law.invention Electrocardiography Postoperative Complications law Internal medicine Troponin I Genotype medicine Cardiopulmonary bypass Humans Platelet Platelet activation Alleles Aged Cardiopulmonary Bypass Polymorphism Genetic business.industry Integrin beta3 Thrombosis Middle Aged Platelet Activation Anesthesiology and Pain Medicine Endocrinology Platelet Glycoprotein IIIa Circulacion extracorporea Cardiology Female Complication business |
Zdroj: | Anesthesiology. 97(5) |
ISSN: | 0003-3022 |
Popis: | Background The PlA2 polymorphism of platelet glycoprotein IIIa has been identified as a prothrombotic risk factor in a number of cardiovascular settings. The aim of this study was to determine whether the PlA2 polymorphism of platelet glycoprotein IIIa and degree of platelet activation were associated with more severe myocardial injury as indicated by troponin I release following cardiopulmonary bypass. Methods The PlA2 genotype was determined in 66 patients undergoing elective coronary artery bypass grafting requiring cardiopulmonary bypass. Troponin I concentrations and the percentage of circulating, activated (CD62P+) platelets were measured at predetermined intervals perioperatively. Results Forty-six patients were Pl(A1,A1), and 20 were Pl(A1,A2) or Pl(A2,A2). Patients with at least one PlA2 allele had significantly greater postoperative troponin I concentrations than PlA1 homozygotes (P = 0.006, analysis of variance). Peak troponin I concentrations also correlated significantly with the increase in circulating, activated platelets (P = 0.02, Spearman rank correlation). Conclusions The PlA2 allele of platelet glycoprotein IIIa is associated with higher troponin I concentrations following cardiopulmonary bypass surgery, suggesting that this platelet polymorphism contributes to perioperative myocardial injury. |
Databáze: | OpenAIRE |
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