Interleukin-1 receptor antagonist, a biomarker of response to anti-TB treatment in HIV/TB co-infected patients

Autor: Daniel Scott-Algara, Yoann Madec, Didier Laureillard, Polidy Pean, François-Xavier Blanc, Janin Nouhin, Céline Didier, Mathieu F. Chevalier, Laurence Weiss, Laurence Borand
Přispěvatelé: VIH/Hépatites, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université Paris Diderot - Paris 7 (UPD7), Immunologie [Phnom Penh], Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Régulation des Infections Rétrovirales, Institut Pasteur [Paris], Unité d'Épidémiologie et de Santé Publique [Phnom Penh], Centre hospitalier universitaire de Nantes (CHU Nantes), Service des maladies infectieuses et tropicales, Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université Sorbonne Paris Cité (USPC), This work was supported by ARI (Association pour la Recherche en Immunopathologie)., We thank all the patients who participated in the study. We also thank the ANRS for authorizing us to use the biobank of CAMELIA and CAPRI-NK for this work., Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Institut Pasteur [Paris] (IP)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Multivariate analysis
MESH: Immune Reconstitution Inflammatory Syndrome*/complications
MESH: Immune Reconstitution Inflammatory Syndrome*/blood
MESH: Biomarkers/blood
[SDV]Life Sciences [q-bio]
MESH: Tuberculosis*/complications
Antitubercular Agents
HIV Infections
urologic and male genital diseases
MESH: Tuberculosis*/blood
0302 clinical medicine
Immune Reconstitution Inflammatory Syndrome
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Macrophage
030212 general & internal medicine
Randomized Controlled Trials as Topic
MESH: Case-Control Studies
female genital diseases and pregnancy complications
3. Good health
TB-IRIS
Infectious Diseases
medicine.anatomical_structure
MESH: Tuberculosis*/drug therapy
Biomarker (medicine)
Female
Fresh frozen plasma
Cambodia
MESH: Immune Reconstitution Inflammatory Syndrome*/diagnosis
Microbiology (medical)
Adult
IL-1 receptor antagonist
MESH: Tuberculosis*/diagnosis
03 medical and health sciences
Immune reconstitution inflammatory syndrome
medicine
Humans
Tuberculosis
Anti-tuberculosis treatment
cardiovascular diseases
HIV/tuberculosis co-infection
MESH: Humans
MESH: HIV Infections/complications
business.industry
urogenital system
Monocyte
fungi
MESH: Adult
medicine.disease
MESH: Antitubercular Agents/therapeutic use
MESH: Male
Interleukin 1 Receptor Antagonist Protein
030104 developmental biology
Interleukin 1 receptor antagonist
MESH: Randomized Controlled Trials as Topic
Case-Control Studies
Immunology
MESH: Interleukin 1 Receptor Antagonist Protein/blood
business
Tb treatment
MESH: Female
Biomarkers
Zdroj: Journal of Infection
Journal of Infection, WB Saunders, 2017, 74 (5), pp.456-465. ⟨10.1016/j.jinf.2017.01.016⟩
Journal of Infection, 2017, 74 (5), pp.456-465. ⟨10.1016/j.jinf.2017.01.016⟩
ISSN: 0163-4453
Popis: International audience; OBJECTIVES: Despite the high frequency of tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in human immunodeficiency virus (HIV)/TB co-infected patients, no diagnostic test is available. Here, we investigated whether monocyte/macrophage activation markers can predict TB-IRIS occurrence and if they are modulated by anti-TB treatment.METHODS: Frozen plasma was obtained from 127 HIV/TB co-infected adults naïve for antiretroviral therapy, enrolled in the CAMELIA trial, 36 of whom developed TB-IRIS. Concentrations of IL-1Ra, sCD14, and sCD163 were measured at anti-TB treatment onset (baseline), after 8 weeks of anti-TB treatment and at TB-IRIS time.RESULTS: At baseline, IL-1Ra and sCD14 concentrations were similar in TB-IRIS and non-IRIS patients. sCD163 concentrations, although significantly higher in TB-IRIS patients, did not remain associated with TB-IRIS occurrence in multivariate analysis. At the time of TB-IRIS, patients displayed higher concentrations of IL-1Ra (p = 0.002) and sCD14 (p < 0.001). The most striking result was the significant decrease in IL-1Ra after 8 weeks of anti-TB treatment (median reduction: -63% (p < 0.0001)).CONCLUSIONS: None of the biomarkers tested was associated with TB-IRIS occurrence. However, repeated measurement of IL-1Ra could help for the diagnosis of TB-IRIS. The substantial reduction of IL-1Ra under treatment suggests that IL-1Ra could be a surrogate biomarker of anti-TB treatment response in HIV-infected patients.
Databáze: OpenAIRE
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