A diet containing grape powder ameliorates the cognitive decline in aged rats with a long-term high-fructose-high-fat dietary pattern
| Autor: | Liang Mao Chou, Shyh Hsiang Lin, Ching I. Lin, Hsiang Liao, Yue Hwa Chen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Aging Endocrinology Diabetes and Metabolism Clinical Biochemistry Spatial Learning Nerve Tissue Proteins Fructose Biology Diet High-Fat Hippocampus Biochemistry Protein expression 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High fat Animals Hippocampus (mythology) Cognitive Dysfunction Vitis Food science Rats Wistar Cognitive decline Molecular Biology Nootropic Agents Cerebral Cortex Neurons Nutrition and Dietetics Behavior Animal Gene Expression Regulation Developmental Polyphenols food and beverages Neurodegenerative Diseases Dietary pattern Freeze Drying 030104 developmental biology chemistry Fruit Dietary Supplements Spatial learning High fructose Diet Carbohydrate Loading 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Nutritional Biochemistry. 34:52-60 |
| ISSN: | 0955-2863 |
| DOI: | 10.1016/j.jnutbio.2016.04.006 |
| Popis: | Research has suggested that the consumption of foods rich in polyphenols is beneficial to the cognitive functions of the elderly. We investigated the effects of grape consumption on spatial learning, memory performance and neurodegeneration-related protein expression in aged rats fed a high-fructose-high-fat (HFHF) diet. Six-week-old Wistar rats were fed an HFHF diet to 66 weeks of age to establish a model of an HFHF dietary pattern, before receiving intervention diets containing different amounts of grape powder for another 12 weeks in the second part of the experiment. Spatial learning, memory performance and cortical and hippocampal protein expression levels were assessed. After consuming the HFHF diet for a year, results showed that the rats fed a high grape powder-containing diet had significantly better spatial learning and memory performance, lower expression of β-amyloid and β-secretase and higher expression of α-secretase than the rats fed a low grape powder-containing diet. Therefore, long-term consumption of an HFHF diet caused a decline in cognitive functions and increased the risk factors for neurodegeneration, which could subsequently be ameliorated by the consumption of a polyphenol-rich diet. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect