Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA
| Autor: | Dana Gabuzda, Paola Cinque, Shibani S. Mukerji, Magnus Gisslén, Edwina J. Wright, Vasudev R Rao, Jeymohan Joseph, Sarah B. Joseph, Ronald Swanstrom, Ignacio Pérez-Valero, Scott Letendre, Serena Spudich, Ameet Dravid, Avindra Nath, Ned Sacktor, Howard S. Fox, Richard W. Price, Alan Winston, Deborah Colosi, Luminita Ene, Deborah Persaud, Valerie Wojna |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Epidemiology Immunology Human immunodeficiency virus (HIV) Disease medicine.disease_cause Microbiology PATIENT 03 medical and health sciences 0302 clinical medicine CEREBROSPINAL-FLUID ANTIRETROVIRAL THERAPY Virology medicine 030212 general & internal medicine Intensive care medicine Science & Technology ENCEPHALITIS business.industry Public Health Environmental and Occupational Health Conference Report VIRAL ESCAPE Mental health QR1-502 Infectious Diseases Public aspects of medicine RA1-1270 business Life Sciences & Biomedicine 030217 neurology & neurosurgery |
| Zdroj: | Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Journal of Virus Eradication, Vol 2, Iss 4, Pp 243-250 (2016) Journal of Virus Eradication |
| Popis: | CSF HIV escape is a recently recognised phenomenon that suggests that despite suppressive treatment, HIV RNA may be detected in the CNS compartment in some individuals. In rare cases this is associated with clinical neurological disease, while in most cases, neurological consequences are not apparent. Attempts at characterising the biological substrates of CSF escape and further investigating the neurological consequences need to be made to better understand the implications of this condition for the HIV cure agenda as well as for clinical outcomes. The Global CSF HIV-1 Escape Consortium meeting, convened by the US National Institute of Mental Health, was a first step to gather investigators from diverse sites to discuss opportunities for future collaborative work on this emerging issue. To better understand CSF HIV escape and allow cross-site data reconciliation, it will be useful to reach a consensus set of definitions of the distinct forms of CSF escape, without which concerted cross-site efforts are difficult. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|