Reversion of cardiovascular remodelling in renovascular hypertensive 2K‐1C rats by renin–angiotensin system inhibitors
| Autor: | Maria Elena Riul, Marcos A. Rossi, José Wilson do Nascimento Corrêa, Cibele M. Prado, Alice Valença Araújo, Lusiane Maria Bendhack |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Intimal hyperplasia Physiology Reversion Angiotensin-Converting Enzyme Inhibitors Blood Pressure Kidney Muscle hypertrophy Vascular remodelling in the embryo Renin-Angiotensin System Angiotensin Receptor Antagonists 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine Renin–angiotensin system medicine Animals Enalapril Pharmacology business.industry medicine.disease Rats Hypertension Renovascular 030104 developmental biology Endocrinology Blood pressure Losartan 030220 oncology & carcinogenesis business medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 47:1965-1977 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1111/1440-1681.13384 |
| Popis: | OBJECTIVES Evaluate whether the RAS dual blockade would induce additional beneficial effects on cardiovascular remodelling when compared to monotherapy in renal hypertensive two kidneys-one clip (2K-1C) rats. METHODS Hypertensive 2K-1C and normotensive (2K) rats were treated for 14 days with submaximal doses of losartan (LOS), enalapril (ENA), losartan plus enalapril (LOS + ENA) or vehicle (water). Blood pressure and some parameters of cardiovascular remodelling were evaluated. RESULTS Systolic blood pressure (SBP) was higher in 2K-1C (209 ± 3 mm Hg, P |
| Databáze: | OpenAIRE |
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